Fig 10. Values of CECF (10-3 μ mol L-1) at several locations within the brain unit for different values of P and vblood at t = 500. a) Locations within the 3D brain unit. Corner 1: (x,y,z) = (r,r,r), Corner 2: (x,y,z) = (xr-r,yr-r,zr-r), Edge: (x,y,z) = (0, yr 2 , zr 2 ), Middle: (x,y,z) = ( xr 2 , yr 2 , zr 2 ). b) Values of CECF are shown for a low ((P = 0.01�10-8 m s-1), default (P = 0.1�10-8 m s-1) and high (P = 1�10-8 m s-1) value of P in the top, middle and bottom table, respectively. Within each table, concentrations are given for several values of vblood (vblood = 0.5�10-4 m s-1, vblood = 5�10-4 m s-1 and vblood = 50�10-4 m s-1, left to right), Tm-in (Tm-in = 0, Tm-in = 1�10-7 μmol s-1, Tm-in = 10�10-7 μmol s-1 and Tm-in = 100�10-7 μmol s-1) and Tm-out (Tm-out = 0, Tm-out = 1�10-7 μmol s-1, Tm-out = 10�10-7 μmol s-1 and Tm-out = 100�10-7 μmol s-1) at different locations. When Tm-in is changed, Tm-out = 0 and vice versa. c) Colour legend. In each table, colours are relative to the value of CECF in the middle of the unit in the absence of active transport for vblood = 5�10-4 m s-1, of which the colour is denoted by “Default”. The intensity of green corresponds to the extent of increase, and the intensity of red corresponds to the extent of decrease of CECF compared to the default. Other parameters are as in Table 2.
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