Fig 5. The effect of active influx on the log concentration-time profiles of drug in the brain ECF, relative to those in the blood plasma. Top: unbound drug in the brain ECF (CECF) compared to unbound drug in the blood plasma (Cpl, red curve). Middle: drug bound to its target sites (B1). Bottom: drug bound to non-specific binding sites (B2). The value of Tm-in is changed from 0 to 100�10-7 μmol s-1. The rest of the parameters are as in Table 2.
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