Fig 6. The effect of active efflux on the log concentration-time profiles of drug in the brain ECF, relative to those in the blood plasma. Top: unbound drug in the brain ECF (CECF) and unbound drug in the blood plasma (Cpl, red curve). Middle: drug bound to its target sites (B1). Bottom: drug bound to non-specific binding sites (B2). The value of Tm-out is changed from 0 to 100�10-7 μmol s-1. The rest of the parameters are as in Table 2.
...read more