Fig 1. Comparison between the model based design (blue) and the rule based design (red) across all simulation scenarios. Panel numbers correspond to the simulation scenario defined in the Methods section. In each panel, the thick lines (shaded areas) show the mean difference (95% interval of variation across trials) between the assigned doses and the simulation true optimal dose. Panels 1-4 show the results for the well-specified scenarios; panels 5-7 for the mis-specified scenarios. Note that each panel has a different y-axis range and the horizontal line shows the 0 y-axis value for reference.
...read more