A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

doi:10.1016/J.CELL.2006.02.041

Open AccessJournal ArticleDOI

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

Bradley E. Bernstein, +17 more

- 21 Apr 2006 -

Cell

- Vol. 125, Iss: 2, pp 315-326

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TLDR

It is proposed that bivalent domains silence developmental genes in ES cells while keeping them poised for activation, highlighting the importance of DNA sequence in defining the initial epigenetic landscape and suggesting a novel chromatin-based mechanism for maintaining pluripotency.

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This article is published in Cell.The article was published on 2006-04-21 and is currently open access. It has received 5131 citations till now. The article focuses on the topics: Bivalent chromatin & DNA methylation.

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Cell

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Ewan Birney, +320 more

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Anshul Kundaje, +123 more

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References

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Nature

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