Figure 1. Experimental paradigm. Participants took part in a double-blind crossover study to test the effects of bumetanide, a drug thought to alter GABAergic action, on binocular rivalry, a noninvasive marker of excitatory-inhibitory balance in visual cortex. After an initial study visit (Day 1; see Materials and Methods), participants returned for two experimental testing days (Day 2 and Day 3). On each experimental day, participants were administered either a placebo or the drug. After waiting for drug absorption, participants completed binocular rivalry and control rivalry replay trials, so that the effect of bumetanide on rivalry dynamics could be assessed.
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