Fig. 2. Molecular diversity of the NINDS-II compound collection screened in this study. (A)Relationship between a molecule and its scaffold, using tranilast as an example. The scaffold or cyclic system is obtained after iteratively removing the side chains and is identified by a five-character chemotype identifier code. The WSLAM scaffold is a singleton, i.e. tranilast is the only compound in the collection with this scaffold. (B)Scaffold-recovery curve. The x-axis represents the
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