Fig. 7. Neurotoxic morphological defects revealed in primary neuron culture. (A-M)Phase-contrast images (60 ) of CNS neurons from sn3/sn3 (A-K) or wildtype (OreR-C; L-M) wandering third instar larvae, cultured for 3 d.i.v. with the following drugs (scale bar in M for images A-M): (A) tannic acid, 50M; (B) 3-3 - diindolylmethane; (C) ginkgolic acid, 50M; (D) tegaserod maleate, 50M; (E) azadirachtin, 50M; (F) 4’-demethylepipodopyllotoxin, 10M; (G) usnic acid, 10M; (H) atorvastatin, 50M; (I) rosuvastatin, 50M; (J) lovastatin, 50M; (K) pravastatin, 50M; (L) atorvastatin, 50M; (M) no-drug control. (N-O)The statininduced BOS defect is modulated by genetic background. Box-plot distributions of the bead density (beads per 100m) along neurites of wild-type (+/+; gray) or fascin-deficient mutant (sn3/sn3; black) larval neurons cultured for 3 d.i.v. with pravastatin (N) or rosuvastatin (O) at the indicated concentrations. The median is
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