Journal ArticleDOI
A clinical overview of IgG4-related systemic disease.
Arezou Khosroshahi,John H. Stone +1 more
Reads0
Chats0
TLDR
IgG4-RSD is an underrecognized condition about which knowledge is now growing rapidly, yet there remain many unknowns with regard to its cause, pathogenesis, various clinical presentations, approach to treatment, disease monitoring, and long-term outcomes.Citations
More filters
Journal ArticleDOI
IgG4-related disease
TL;DR: Identification of specific antigens and T-cell clones that drive the disease will be the first steps to elucidate the pathogenesis of IgG4-related disease.
Journal ArticleDOI
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details
Hisanori Umehara,Kazuichi Okazaki,Yasufumi Masaki,Mitsuhiro Kawano,Motohisa Yamamoto,Takako Saeki,Shoko Matsui,Takayuki Sumida,Tsuneyo Mimori,Yoshiya Tanaka,Kazuo Tsubota,Tadashi Yoshino,Shigeyuki Kawa,Ritsuro Suzuki,Tsutomu Takegami,Naohisa Tomosugi,Nozomu Kurose,Yasuhito Ishigaki,Atsushi Azumi,Masaru Kojima,Shigeo Nakamura,Dai Inoue +21 more
TL;DR: Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG 4.
Journal ArticleDOI
Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations
John H. Stone,Arezou Khosroshahi,Vikram Deshpande,John K.C. Chan,J. Godfrey Heathcote,Rob C. Aalberse,Atsushi Azumi,Daniel Bloch,William R. Brugge,Mollie N. Carruthers,Wah Cheuk,Lynn D. Cornell,Carlos Fernandez-del Castillo,Judith A. Ferry,David G. Forcione,Günter Klöppel,Daniel L. Hamilos,Terumi Kamisawa,Satomi Kasashima,Shigeyuki Kawa,Mitsuhiro Kawano,Yasufumi Masaki,Kenji Notohara,Kazuichi Okazaki,Ji Kon Ryu,Takako Saeki,Dushyant V. Sahani,Yasuharu Sato,Thomas C. Smyrk,James R. Stone,Masayuki Takahira,Hisanori Umehara,George Webster,Motohisa Yamamoto,Eunhee S. Yi,Tadashi Yoshino,Giuseppe Zamboni,Yoh Zen,Suresh T. Chari +38 more
TL;DR: John H. Stone, Arezou Khosroshahi, Vikram Deshpande, John K.Stone, Masayuki Takahira, Hisanori Umehara, George Webster, Motohisa Yamamoto, Eunhee Yi, Tadashi Yoshino, Giuseppe Zamboni, Yoh Zen, and Suresh Chari.
Journal ArticleDOI
Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients.
Arezou Khosroshahi,Mollie N. Carruthers,Vikram Deshpande,Sebastian Unizony,Daniel Bloch,John H. Stone +5 more
TL;DR: Treatment with RTX led to prompt clinical and serologic improvement in refractory IgG4-RD in all patients with active inflammation, and Serial treatments with RTX may lead to progressive declines in serum IgG 4 concentrations and better disease control.
Journal ArticleDOI
IgG4-related disease.
TL;DR: The diagnosis of IgG4-RD unifies many eponymous fibroinflammatory conditions that had previously been thought to be confined to single organs and is now being recognized with increasing frequency.
References
More filters
Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
TL;DR: Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.
Journal ArticleDOI
Chronic pancreatitis caused by an autoimmune abnormality : proposal of the concept of autoimmune pancreatitis
Kenji Yoshida,Fumitake Toki,Tadashi Takeuchi,Shin-ichiro Watanabe,Keiko Shiratori,Naoaki Hayashi +5 more
TL;DR: In this paper, the authors reported a case of chronic pancreatitis in which an autoimmune mechanism is involved in the etiology and summarized the cases of pancreatitis suspected of being caused by an auto-antibody-positive mechanism in the Japanese and English literature.
Journal ArticleDOI
A new clinicopathological entity of IgG4-related autoimmune disease
Terumi Kamisawa,Nobuaki Funata,Yukiko K. Hayashi,Yoshinobu Eishi,Morio Koike,Kouji Tsuruta,Atsutake Okamoto,Naoto Egawa,Hitoshi Nakajima +8 more
TL;DR: It is suggested that AIP is not simply pancreatitis but that it is a pancreatic lesion involved in IgG4-related systemic disease with extensive organ involvement, and a new clinicopathological entity is proposed.
Journal ArticleDOI
Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience.
Suresh T. Chari,Thomas C. Smyrk,Michael J. Levy,Mark Topazian,Naoki Takahashi,Lizhi Zhang,Jonathan E. Clain,Randall K. Pearson,Bret T. Petersen,Santhi Swaroop Vege,Michael B. Farnell +10 more
TL;DR: D diagnosis of autoimmune pancreatitis can be made in patients with > or =1 of these criteria: diagnostic histology, characteristic imaging on computed tomography and pancreatography with elevated serum IgG4 level, or response to steroid therapy of pancreatic/extrapancreatic manifestations of AIP.
Journal ArticleDOI
Immunoglobulin G4–Associated Cholangitis: Clinical Profile and Response to Therapy
Amaar Ghazale,Suresh T. Chari,Lizhi Zhang,Thomas C. Smyrk,Naoki Takahashi,Michael J. Levy,Mark Topazian,Jonathan E. Clain,Randall K. Pearson,Bret T. Petersen,Santhi Swaroop Vege,Keith D. Lindor,Michael B. Farnell +12 more
TL;DR: IAC should be suspected in unexplained biliary strictures associated with increased serum IgG4 and unexplained pancreatic disease, especially with proximal strictures, and the role of immunomodulatory drugs for relapses needs further study.
Related Papers (5)
Consensus statement on the pathology of IgG4-related disease
Vikram Deshpande,Yoh Zen,John Kc Chan,Eunhee E Yi,Yasuharu Sato,Tadashi Yoshino,Günter Klöppel,J. Godfrey Heathcote,Arezou Khosroshahi,Judith A. Ferry,Rob C. Aalberse,Daniel Bloch,William R. Brugge,Adrian C Bateman,Mollie N. Carruthers,Suresh T. Chari,Wah Cheuk,Lynn D. Cornell,Carlos Fernandez-del Castillo,David G. Forcione,Daniel L. Hamilos,Terumi Kamisawa,Satomi Kasashima,Shigeyuki Kawa,Mitsuhiro Kawano,Gregory Y. Lauwers,Yasufumi Masaki,Yasuni Nakanuma,Kenji Notohara,Kazuichi Okazaki,Ji Kon Ryu,Takako Saeki,Dushyant V. Sahani,Thomas C. Smyrk,James Robert Stone,Masayuki Takahira,George Webster,Motohisa Yamamoto,Giuseppe Zamboni,Hisanori Umehara,John H. Stone +40 more
Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011
Hisanori Umehara,Kazuichi Okazaki,Yasufumi Masaki,Mitsuhiro Kawano,Motohisa Yamamoto,Takako Saeki,Shoko Matsui,Tadashi Yoshino,Shigeo Nakamura,Shigeyuki Kawa,Hideaki Hamano,Terumi Kamisawa,Toru Shimosegawa,Akira Shimatsu,Seiji Nakamura,Tetsuhide Ito,Kenji Notohara,Takayuki Sumida,Yoshiya Tanaka,Tsuneyo Mimori,Tsutomu Chiba,Michiaki Mishima,Toshifumi Hibi,Hirohito Tsubouchi,Kazuo Inui,Hirotaka Ohara +25 more