A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

doi:10.1093/AJCP/28.1.56

Journal Article•DOI•

A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

Stanley Reitman¹, Sam Frankel¹•Institutions (1)

01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63

About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.

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Journal Article•DOI•

Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat.

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Sana Janakat¹, Hela Al-Merie¹•Institutions (1)

Jordan University of Science and Technology¹

01 Jul 2002-Journal of Pharmacological and Toxicological Methods

TL;DR: The optimum intraperitoneal dose of CCl(4) was found to be 2 ml/kg body weight (dissolved in an equal volume of olive oil), and this increased the level of bilirubin and the activity of the three enzymes significantly, without causing death of the animals.

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59 citations

Book•

Toxicological effects of zinc oxide nanoparticles: Ecotoxicological effect of sublethal exposure to zinc oxide nanoparticles on freshwater snail Biomphalaria alexandrina

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Sohair R. Fahmy, Fathy Abdel-Ghaffar, Dawlat A Sayed

08 Oct 2014

TL;DR: This study highlights the potential ecological implications of ZnONP release in aquatic environments and may serve to encourage regulatory agencies in Egypt to more carefully monitor and regulate the industrial use and disposal of ZNONPs.

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Abstract: Freshwater snails are used as sensitive biomarkers of aquatic ecosystem pollution. The potential impacts of zinc oxide nanoparticles (ZnONPs) on aquatic ecosystems have attracted special attention due to their unique properties. The present investigation was designed to evaluate the possible mechanisms of ecotoxicological effects of ZnONPs on freshwater snail Biomphalaria alexandrina. ZnONPs showed molluscicidal activity against B. alexandrina snails, and the LC50 was 145 μg/ml. Two tested concentrations of ZnONPs were selected: The first concentration was equivalent to LC10 (7 μg/ml), and the second was equivalent to LC25 (35 μg/ml). Exposure to ZnONPs (7 and 35 μg/ml) for three consecutive weeks significantly induced malondialdehyde and nitric oxide with concomitant decreases in glutathione and glutathione-S-transferase levels in hemolymph and soft tissues of treated snails. Moreover, ZnONPs elicited a significant decrease in total protein and albumin contents coinciding with enhancement of total lipids and cholesterol levels as well as activities of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase in hemolymph and soft tissues of treated snails. This study highlights the potential ecological implications of ZnONP release in aquatic environments and may serve to encourage regulatory agencies in Egypt to more carefully monitor and regulate the industrial use and disposal of ZnONPs.

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59 citations

Cites background from "A colorimetric method for the deter..."

...ferase [AST] and alanine aminotransferase [ALT]) (Reitman and Frankel 1957), and alkaline phosphatase (ALP;...
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...…(Tietz 1994), albumin (Tietz 1994), total lipids (Zollner and Kirsch 1962), total cholesterol (Allain et al. 1974), aminotransferase enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) (Reitman and Frankel 1957), and alkaline phosphatase (ALP; Belfield and Goldberg 1971)....
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Journal Article•DOI•

Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents

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Talib Hussain¹, Talib Hussain², Ramesh K Gupta², K Sweety², Mohd Sajid Khan¹, Sarfaraj Hussain¹, Arif¹, Arshad Hussain¹, Faiyazuddin¹, Chandana Venkateswara Rao² - Show less +6 more•Institutions (2)

Integral University¹, National Botanical Research Institute²

01 Jun 2012-Asian pacific Journal of Tropical Biomedicine

TL;DR: The results of this study strongly indicate the protective effect of S. xanthocarpum against liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use.

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Abstract: Objective To assess the hepatoprotective effect of Solanum xanthocarpum (S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.

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59 citations

Cites methods from "A colorimetric method for the deter..."

...parameters like serum enzymes: aspartate aminotransferase (AST, U/L), alanine aminotransferase (ALT, U/L)[22], alkaline phosphatase (ALP, U/L)[23], total bilirubin (TBL, mg/dL)[24], albumin (ALB, g/dL)[25], total protein (TP, g/dL)[25], lactate dehydroginase (LDH, U/L)[26] and total cholesterol (CHL, g/ dL)[27] were assayed using assay kits....
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...Assessment of hepatoprotective activity The collected blood was allowed to clot and serum was separated at 2 500 rpm for 15 min and the biochemical Talib Hussain et al./Asian Pacific Journal of Tropical Biomedicine (2012)454-460456 parameters like serum enzymes: aspartate aminotransferase (AST, U/L), alanine aminotransferase (ALT, U/L)[22], alkaline phosphatase (ALP, U/L)[23], total bilirubin (TBL, mg/dL)[24], albumin (ALB, g/dL)[25], total protein (TP, g/dL)[25], lactate dehydroginase (LDH, U/L)[26] and total cholesterol (CHL, g/ dL)[27] were assayed using assay kits....
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Journal Article•DOI•

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways.

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Erika Hernández-Aquino¹, Natanael Zarco¹, Sael Casas-Grajales¹, Erika Ramos-Tovar¹, Rosa E. Flores-Beltrán¹, Jonathan Arauz¹, Mineko Shibayama¹, Liliana Favari¹, Víctor Tsutsumi¹, José Segovia¹, Pablo Muriel¹ - Show less +7 more•Institutions (1)

CINVESTAV¹

28 Jun 2017-World Journal of Gastroenterology

TL;DR: NAR prevents CCl4 induced liver inflammation, necrosis and fibrosis, due to its antioxidant capacity as a free radical inhibitor and by inhibiting the NF-κB, TGF-β- Smad3 and JNK-Smad3 pathways.

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Abstract: Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

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59 citations

Journal Article•DOI•

Familial intrauterine convulsions in pyridoxine dependency.

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M. Bejsovec, Z. Kulenda, E. Ponca

01 Apr 1967-Archives of Disease in Childhood

TL;DR: The present report concerns three sibs, in all of whom the mother noted intrauterine convulsions: the first two died in status epilepticus and the third survived thanks to pyridoxine treatment, and biochemical studies were undertaken after birth.

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Abstract: Pyridoxine dependency is a relatively rare congenital metabolic disturbance. To date 16 patients have been reported who survived (Schmidt, 1964), and probably 7 of their sibs died because the disease was not recognized in time. The present report concerns the first cases observed in Czechoslovakia. Intrauterine convulsions are even rarer. Only two cases have been described (Badr-El-Din, 1960; Isler, 1964) and one mentioned in passing (Ford, 1960). Only one author (Badr-El-Din, 1960) mentions familial intrauterine convulsions, but there was no suggestion of a connexion between familial intrauterine convulsions and either congenital metabolic disturbance or pyridoxine dependency. For this reason we think our observations will be of interest. The present report concerns three sibs, in all of whom the mother noted intrauterine convulsions: the first two died in status epilepticus. The third survived thanks to pyridoxine treatment, and biochemical studies were undertaken after birth.

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59 citations

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A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

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