A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63
About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.
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TL;DR: Hemionitis arifolia, a folklore anti-diabetes fern, was evaluated for its hypoglycaemic andAnti-diabetic properties using rats and it was devoid of conspicuous toxic symptoms in sub-acute toxicity evaluation in mice.
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TL;DR: It can be concluded that ALA may be a promising therapeutic option for prevention and (or) treatment of deltamethin toxicity.
Abstract: Alpha-lipoic acid (ALA) is a natural dithiol compound, with a free radical scavenger and biological antioxidant properties. The purpose of the current study was to investigate the protective effects of ALA on biochemical alteration and oxidative stress induced by acute deltamethrin intoxication in rats. Markers of liver and kidney injuries in serum of deltamethrin-intoxicated as well as ALA-pretreated rats were analyzed. Moreover, serum and (or) tissue lipid peroxidation, malondialdehyde and antioxidant markers, reduced glutathione, catalase, superoxide dismutase activity, and total antioxidant capacity were evaluated. The results showed that all parameters were altered in the intoxicated group, indicating hepatorenal oxidative damage of deltamethrin. Pre-treatment with ALA reversed the changes in most of the studied parameters in a dose-dependent manner. Histopathological and biochemical findings were parallel. It can be concluded that ALA may be a promising therapeutic option for prevention and (or) treatment of deltamethin toxicity.
59 citations
Cites methods from "A colorimetric method for the deter..."
...Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were evaluated according to (Reitman and Frankel 1957), Alkaline phosphatase (ALP) according to (Tietz et al. 1983), serum total protein was measured according to (Lowry et al. 1951), total bilirubin (TB) was determined…...
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TL;DR: The effect exerted by BDMC-A was found to be more promising than curcumin, and Histopathological studies of liver also showed protective effect ofCurcumin and BD MC-A.
Abstract: We have evaluated the comparative effect of curcumin (diferuloyl methane) and its analogue [bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione] (BDMC-A) on carbon tetrachloride-induced hepatotoxicity in rats. Administration of carbon tetrachloride (3 ml/kg/week) for three months significantly (P<0.05) increased the levels of marker enzymes such as aspartate transaminase (AST), alkaline phosphatase (ALP) and γ-glutamyl transferase (GGT). The levels of plasma thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides were also significantly (P<0.05) increased. We have observed a significant (P<0.05) decrease in the levels of plasma reduced glutathione (GSH), vitamin C and vitamin E. There was a significant (P<0.05) increase in the levels of TBARS and hydroperoxides in liver and kidney and a significant (P<0.05) decrease in the activities of enzymic antioxidants- superoxide dismutase (SOD), catalase and GSH peroxidase along with GSH in CCl4-treated rats. Oral administration of curcumin and BDMC-A to CCl4-induced rats for a period of three months significantly (P<0.05) decreased the levels of marker enzymes, plasma TBARS and hydroperoxides and increased the levels of plasma and tissue antioxidants. Histopathological studies of liver also showed protective effect of curcumin and BDMC-A. We have observed thickening of blood vessels and microvesicular fatty changes around the portal triad in CCl4-treated rat liver. Treatment with curcumin showed only mild sinusoidal dilatation while with BDMC-A there was only mild portal inflammation. The effect exerted by BDMC-A was found to be more promising than curcumin.
59 citations
TL;DR: Results revealed that QE is able to significantly alleviate the toxicity induced by AA in rats, which was confirmed by decreased acetylcholinesterase (AChE) activity.
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TL;DR: The studies revealed significant and concentration dependent hepatoprotective potential of ‘IF’ as it reversed the majority of the altered hepatic parameters in experimental liver damage in rodents.
Abstract: Iridoid enriched fraction IF from the ethanol-water extract of aerial parts (leaves and stems) of Barleria prionitis Linn. was evaluated for hepatoprotective activity in various acute and chronic animal test models of hepatotoxicity. It afforded significant hepatoprotection against carbon tetrachloride, galactosamine and paracetamol induced hepatotoxicity. Silymarin, was used as reference hepatoprotective. In the safety evaluation study the oral LD50 was found to be more than 3000 mg/kg, with no signs of abnormalities or any mortality observed for 15 days period under observation after single dose of drug administration whereas intraperitoneal LD50 was found to be 2530 mg/kg ± 87 mg/kg. SE (n = 10) in mice. The studies revealed significant and concentration dependent hepatoprotective potential of ‘IF’ as it reversed the majority of the altered hepatic parameters in experimental liver damage in rodents. Copyright © 2005 John Wiley & Sons, Ltd.
59 citations