A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63
About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.
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TL;DR: It is concluded that administration of L-ascorbic acid to arsenic affected population may prevent the occurrence of fatal human diseases.
Abstract: A study, so as to confirm the protective effects of L-ascorbic acid against inorganic arsenic (As 2 O 3 ) toxicity was made in male Wistar rats. Multiphase observations made on iAs concentration in target organs viz. liver and kidney, liver function, histopathological changes, ultrastructural alterations, lipid peroxidation, oxidative stress and iAs-DNA interaction strongly favoured its ameliorative effects. These effects could mainly be attributed to its antioxidative property. It offers help in regeneration of GSH and α-tocopherol. The chelation of iAs by ascorbic acid has also been hypothesized. Inhibition of DNA damage by ascorbic acid in liver and kidney appears to be the most significant part of this study. On the basis of these results, we conclude that administration of L-ascorbic acid to arsenic affected population may prevent the occurrence of fatal human diseases.
56 citations
Cites methods from "A colorimetric method for the deter..."
...activity in serum were determined following the method of Reitman and Frankel (1957) using a kit procured from Span Diagnostics (Surat, Gujrat)....
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TL;DR: In this paper, cold-pressed S. aromaticum oil (CO) was administered to rats in two doses (100 and 200 mg/kg) along with CCl4 (1 mL/kg in olive oil) for 8 weeks.
Abstract: Contexts: Exposure to environmental pollutants such as carbon tetrachloride (CCl4) causes liver injuries. There are claims that extracts from Syzygium aromaticum (Linn.) Merrill & L.M.Perry, (Myrtaceae) protects from such injuries.Objective: This study investigates the protective effects of cold-pressed S. aromaticum oil (CO) against CCl4-induced liver toxicity in rats.Materials and methods: CO was orally administered to rats in two doses (100 and 200 mg/kg) along with CCl4 (1 mL/kg in olive oil) for 8 weeks. Indices of liver and kidney functions, lipid profile, and peroxidation were evaluated in rats’ serum and tissues. Fatty acids and bioactive lipids of CO were analyzed.Results: High levels of monounsaturated fatty acids (39.7%) and polyunsaturated fatty acids (42.1%) were detected in CO. The oil contained high amounts of tocols and phenolics. The LD50 value at 24 h was approximately 5950 mg/kg. Treatment with 200 mg/kg CO resulted in a decrease of creatinine, urea, and uric acid levels to 0.86...
55 citations
Cites methods from "A colorimetric method for the deter..."
...…transaminase (AST), alkaline phosphatase (ALP) as well as the serum total bilirubin (TB), direct bilirubin (DB), total protein and serum albumin were determined according to the methods of Reitman and Frankel (1957), Tietz et al. (1983), Doumas et al. (1973), and Doumas et al. (1971), respectively....
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TL;DR: CPF caused dose-related histopathological changes in liver and kidney of the CPF-treated dams, and significant damage to liver was observed via increased plasma levels of aminotransferases and lactate dehydrogenase and γ-glutamyle transferase.
Abstract: This study was conducted to shed light on the effect of exposure of lactating rat to chlorpyrifos (CPF). CPF was orally administered to lactating rats at 0.01 mg kg-1 b.wt. (acceptable daily intake...
55 citations
Cites methods from "A colorimetric method for the deter..."
...The measurement of plasma cellular enzymes such as aminotransferases (AST; EC 2.6.1.1 and ALT; EC 2.6.1.2), lactate dehydrogenase (LDH; EC 1.1.1.27) and g-glutamyltransferase (GGT) were determined by the methods of Reitman and Frankel (1957), Tietz (1995) and Szasz (1969), respectively....
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TL;DR: The dose dependent effects of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid to offset the characteristic biochemical, immunological, oxidative stress consequences and DNA damage following sub-chronic administration of Gallium arsenide and the mobilization of gallium and arsenic were examined.
55 citations
TL;DR: The results suggest that the interaction between chlordecone and CCl4 is a subtle one, not causally involving increased covalent binding of the toxin, increased susceptibility of tissue lipids to peroxidative damage or decreased hepatic GSH.
55 citations