A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

doi:10.1093/AJCP/28.1.56

Journal Article•DOI•

A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

Stanley Reitman¹, Sam Frankel¹•Institutions (1)

01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63

About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.

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Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats

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Ming-Yu Hung¹, Timothy Yu-Chi Fu, Ping-Hsiao Shih¹, Chia-Pu Lee¹, Gow-Chin Yen¹ - Show less +1 more•Institutions (1)

National Chung Hsing University¹

01 Aug 2006-Food and Chemical Toxicology

TL;DR: Oral administration with WEDZ for 28 consecutive days significantly decrease the intensity of hepatic damage induced by CCl4 in rats, and Liver histopathology showed that WEDz or PCA reduced the incidence of liver lesions.

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130 citations

Journal Article•DOI•

Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats.

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S. R. Suja¹, P.G. Latha¹, Palpu Pushpangadan², S. Rajasekharan¹•Institutions (2)

Jawaharlal Nehru Tropical Botanic Garden and Research Institute¹, National Botanical Research Institute²

01 May 2004-Journal of Ethnopharmacology

TL;DR: The results showed that significant hepatoprotective effect was obtained against CCl4-induced liver damage, by oral administration of Helminthostachys zeylanica methanolic extract as evident from decreased levels of serum enzymes and an almost normal architecture of the liver, in the treated groups, compared to the controls.

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130 citations

Journal Article•DOI•

Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats

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Rangachari Balamurugan¹, Veeramuthu Duraipandiyan¹, Savarimuthu Ignacimuthu¹•Institutions (1)

Loyola College, Chennai¹

30 Sep 2011-European Journal of Pharmacology

TL;DR: Results indicated that γ-sitosterol, the compound isolated from L. nodiflora, possessed antihyperglycemic activity and its protective role against liver damage.

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130 citations

Journal Article•DOI•

Enhanced therapeutic potential of naringenin-phospholipid complex in rats.

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Kuntal Maiti¹, Kakali Mukherjee¹, Arunava Gantait¹, Bishnu Pada Saha¹, Pulok K. Mukherjee¹ - Show less +1 more•Institutions (1)

Jadavpur University¹

18 Feb 2010-Journal of Pharmacy and Pharmacology

TL;DR: Phospholipid complex of naringenin produced better antioxidant activity than the free compound with a prolonged duration of action, which may be helpful in reducing the fast elimination of the molecule from body.

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Abstract: Naringenin is a naturally occurring flavanone, possessing a variety of biological activity. Due to its rapid elimination, naringenin needs frequent administration to maintain an effective plasma concentration. We have evaluated the therapeutic potential of naringenin-phospholipid complex under oxidative stress conditions compared with free naringenin. Naringenin-phospholipid complex was prepared and assessed for antioxidant activity in carbon tetrachloride intoxicated rats at a dose level of 100 mg kg-1 (p.o.). Liver function tests were studied by assessing serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase and total bilirubin. Marker enzymes of liver, namely glutathione peroxidase, superoxide dismutase, catalase and thiobarbituric acid reactive substances, were measured to evaluate the antioxidant potential at the same dose level. The plasma concentration of naringenin was also measured. It was observed that the naringenin-phospholipid complex enhanced the antioxidant activity of the biomolecule and protected the liver significantly for a longer time as compared with free naringenin at the same dose level. Phospholipid complex of naringenin produced better antioxidant activity than the free compound with a prolonged duration of action, which may be helpful in reducing the fast elimination of the molecule from body.

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129 citations

Cites methods from "A colorimetric method for the deter..."

...Liver function tests were performed by measuring serum glutamate oxaloacetae transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) (Reitman & Frankel 1957), serum alkaline phosphatase (SALP) (Kind & King 1954) and total bilirubin (Malloy & Erelyn 1937)....
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...Hepatic damage induced by CCl4 caused a significant rise in marker enzymes SGPT, SGOT, SALP and in serum bilirubin....
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...Liver function tests and the antioxidant activity studies (Tables 1 and 2) showed that pretreatment with pure naringenin (100 mg kg−1) on alternate days neither reduced the elevated levels of SGOT, SGPT, SALP, total bilirubin and TBARS, nor increased the depleted levels of GPX, SOD and catalase....
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Journal Article•DOI•

Hepatoprotective activity of Amaranthus spinosus in experimental animals

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Hussain Zeashan¹, G. Amresh¹, Satyawan Singh, Chandana Venkateswara Rao¹•Institutions (1)

Council of Scientific and Industrial Research¹

01 Nov 2008-Food and Chemical Toxicology

TL;DR: The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus was evaluated against carbon tetrachloride induced hepatic damage in rats and suggests that possible mechanism of this activity may be due to the presence of flavonoids and phenolics compound in the ASE.

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129 citations

Cites background or methods from "A colorimetric method for the deter..."

...The collected blood was allowed to clot and serum was separated at 2500 rpm for 15 min and the biochemical parameters like serum enzymes: aspartate aminotransferase (AST, U/L), serum glutamate pyruvate transaminase (ALT, U/L) (Reitman and Frankel, 1957), serum alkaline phosphatase (ALP, IU/L) (King, 1965) and total bilirubin (mg/dL) (Malloy and Evelyn, 1937) were assayed using assay kits....
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...…15 min and the biochemical parameters like serum enzymes: aspartate aminotransferase (AST, U/L), serum glutamate pyruvate transaminase (ALT, U/L) (Reitman and Frankel, 1957), serum alkaline phosphatase (ALP, IU/L) (King, 1965) and total bilirubin (mg/dL) (Malloy and Evelyn, 1937) were assayed…...
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...transferase (AST, U/L), serum glutamate pyruvate transaminase (ALT, U/L) (Reitman and Frankel, 1957), serum alkaline phosphatase (ALP, IU/L) (King, 1965) and total...
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A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

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