A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63
About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.
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TL;DR: Hemperidin proved to be better than indomethacin and naringin because of more pronounced pharmacological actions without tissue toxicity, and both naring in and hesperid in are anti-inflammatory and antioxidative in nature.
Abstract: Anti-inflammatory and antioxidative potential of hesperidin and naringin was carried out considering the rat air pouch model of inflammation. Reference dose of hesperidin (H) or naringin (N) or indomethacin (I) was administered to the rat air pouches. The pouches were induced by injecting sterile air into the intra-scapular region of the rats followed by carrageenan (AP + C) administration. Rats injected only with air (AP) served as controls. The AP + C group, showed an increase in the exudate lipid peroxidation (LPO), reduced glutathione (GSH), TNF-α, activity of catalase (CAT), total leukocytes and neutrophils along with tissue edema and infiltration of inflammatory cells. Increases in tissue nitrite, LPO, GSH, SOD (superoxide dismutase) and CAT were recorded. Increased CAT and SGPT with concomitant decrease in ALP were observed in serum. When treated with indomethacin (AP + C + I), all the alterations in the exudate, tissue and serum shifted towards normalcy, except LPO in exudate and nitrite in tissue, while, hesperidin (AP + C + H) or naringin (AP + C + N) treatment normalized all the alterations. It seems that both naringin and hesperidin are anti-inflammatory and antioxidative in nature, but hesperidin proved to be better than indomethacin and naringin because of more pronounced pharmacological actions without tissue toxicity.
119 citations
Cites methods from "A colorimetric method for the deter..."
...Estimation of the activities of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were carried out by following Rietman and Frankel’s method [26], whereas alkaline phosphatase (ALP) activity was measured by following the protocol of Bessey et al....
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TL;DR: Pretreatment with latex particles suppressed the free radical‐generating capacity of hepatic macrophages and protected against hepatic injury induced by galactosamine, suggesting that liver injuryinduced by galactsamine is modulated by oxygen‐derived free radicals from hepatic Macrophages.
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TL;DR: This study provides a scientific basis for the ethnomedical claims that Parathelypteris nipponica (Franch. et Sav.) Ching is effective against inflammation and liver injury.
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Cites methods from "A colorimetric method for the deter..."
...Assessment of hepatoprotective activity Hepatic enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were used as the biochemical markers of the hepatic damage and were assayed by the method of (Reitman and Frankel, 1957)....
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TL;DR: Sea cucumber mixed extract contains physiologically active phenolic compounds with antioxidant activity, which afforded a potential hepatoprotective activity against thioacetamide-induced liver injury in a rat model.
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TL;DR: Results of this study revealed that Cichorium intybus root callus extract could afford a better protection against carbon tetrachloride induced heptocellular damage as compared to the natural root extract.
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