A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

doi:10.1093/AJCP/28.1.56

Journal Article•DOI•

A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

Stanley Reitman¹, Sam Frankel¹•Institutions (1)

01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63

About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.

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Journal Article•DOI•

Metabolic effects of technical pentachlorophenol (PCP) on the eel Anguilla anguilla L.

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Bo Holmberg, Sören Jensen¹, Åke Larsson, Kerstin Lewander, Mats Olsson² - Show less +1 more•Institutions (2)

Stockholm University¹, Swedish Museum of Natural History²

15 Sep 1972-Comparative Biochemistry and Physiology B

TL;DR: Eels exposed to sea water and fresh water containing 0·1 ppm pentachlorophenol caused changes that indicated a hypermetabolic state with accelerated utilization of tissue energy reserves and an enlargement of the liver suggested a disturbed liver function.

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Abstract: 1. 1. Eels ( Anguilla anguilla L.) were exposed to sea water and fresh water containing 0·1 ppm pentachlorophenol (PCP). The accumulation of the pesticide as well as the effects on different metabolites in blood, muscle and l liver were studied. 2. 2. PCP exposure caused changes, which indicated a hypermetabolic state with accelerated utilization of tissue energy reserves. 3. 3. An altered cholesterol metabolism, a decreased activity of liver glutamate pyruvate transaminase (GPT) and an enlargement of the liver suggested a disturbed liver function. 4. 4. The effects of PCP seemed to persist in spite of a recovery period in clean water for about 2 months.

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101 citations

Journal Article•DOI•

Hepatoprotective activity of Andrographis Paniculata and Swertia Chirayita

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R.b Nagalekshmi, Aditya Menon, Dhanya K. Chandrasekharan, Cherupally Krishnan Krishnan Nair

01 Dec 2011-Food and Chemical Toxicology

TL;DR: The present study revealed that the extracts of A. paniculata or S. chirayita offered protection against hepatotoxicity induced by paracetamol.

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101 citations

Journal Article•

Experimental Studies of Factors Influencing Hepatic Metastases

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Edwin R. Fisher, Bernard Fisher

01 May 1962-Cancer Research

TL;DR: Evidence is considered against a functional role of the reticuloendothelial system in the process of metastases in the experimental model utilized and the significance of sinusoidal compression with resultant trapping of tumor cells within the liver in accounting for the effects noted.

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Abstract: Effective reticuloendothelial stimulation produced by Proferrin prior to the intraportal injection of Walker carcinoma cells resulted in a twofold increase in the number of animals exhibiting artificially induced metastases. In addition, the degree of hepatic involvement with tumor was approximately twice as great in these animals as in untreated controls. Although similar reticuloendothelial stimulation resulted from appropriate injections of BCG or endotoxin, no effect on the incidence or degree of hepatic involvement by these lesions was observed. All agents utilized were associated with alterations of serum glutamic oxalacetic and/or pyruvic transaminases, but only Proferrin produced sinusoidal compression due to swelling of Kupffer cells. This information, together with the previously noted augmentation of such lesions observed following reticuloendothelial blockade, is considered as strong evidence against a functional role of the reticuloendothelial system in the process of metastases in the experimental model utilized. It also indicates the significance of sinusoidal compression with resultant trapping of tumor cells within the liver in accounting for the effects noted.

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101 citations

Journal Article•DOI•

Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family

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Bahar Ahmed¹, Tanveer Alam¹, Manoj Varshney¹, Shah Alam Khan¹•Institutions (1)

Jamia Hamdard¹

01 Mar 2002-Journal of Ethnopharmacology

TL;DR: The methanolic extracts showed the most significant hepatoprotective activity comparable with standard drug silymarin, and other extracts namely petroleum ether and acetone also exhibited a potent activity.

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101 citations

Cites methods from "A colorimetric method for the deter..."

...…biochemical parameters: serum transaminases viz. glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (SALP), total protein (TP) and albumin (TA) according to the reported methods (Reitman and Frankel, 1957; Kind and King, 1954; Wooton, 1964)....
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Journal Article•DOI•

Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats

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Ali Akbar Abolfathi¹, Daryoush Mohajeri¹, Ali Rezaie¹, Mehrdad Nazeri¹•Institutions (1)

Islamic Azad University¹

21 Feb 2012-Evidence-based Complementary and Alternative Medicine

TL;DR: The hepatoprotective activity of GTE was proved in experimentally induced diabetic rats, and changes were in the same direction with biochemical findings as well as Histopathologically.

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Abstract: Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes. This study was designed to evaluate the hepatoprotective properties of green tea extract (GTE) in STZ-induced diabetes in rats. Wistar rats were made diabetic through single injection of STZ (75 mg/kg i.p.). The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2, nondiabetics treated with GTE administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with GTE (1.5%, w/v) for 8 weeks. Serum biomarkers were assessed to determine hepatic injury. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) were also determined. The biochemical findings were matched with histopathological verifications. Liver MDA content and serum levels of ALT, AST, ALP, and bilirubin in Group 3 significantly increased compared to Group 1 () and significantly decreased in Group 4 compared to Group 3 (). Serum albumin level and GSH, SOD, CAT, and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Group 1 () and were significantly increased in Group 4 compared to Group 3 (). Histopathologically, the changes were in the same direction with biochemical findings. This study proved the hepatoprotective activity of GTE in experimentally induced diabetic rats.

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100 citations

Cites methods from "A colorimetric method for the deter..."

...Aminotransferases (ALT and AST) were measured to determine the concentration of intracellular hepatic enzymes that have leaked into the circulation and serve as a marker of hepatocyte injury....
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...Liver MDA content and serum levels of ALT, AST, ALP, and bilirubin in Group 3 significantly increased compared to Group 1 (P 0.05) and significantly decreased in Group 4 compared to Group 3 (P 0.05)....
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...Increase in serum levels of AST shows hepatic injuries similar to viral hepatitis, infarction, and muscular damages....
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...ALT, AST, ALP and bilirubin serum contents in Group 3 were found to be significantly increased as compared to Group 1 (P 0.05) and these parameters in Group 4 were significantly decreased as compared to Group 3 (P 0.05)....
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...Figures 2, 3, 4, 5, and 6 show the effects of GTE on the serum levels of markers of liver injury (ALT, AST, ALP, and bilirubin) in diabetic rats....
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A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

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