A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
01 Jul 1957-American Journal of Clinical Pathology (AMERICAN JOURNAL OF CLINICAL PATHOLOGY)-Vol. 28, Iss: 1, pp 56-63
About: This article is published in American Journal of Clinical Pathology.The article was published on 1957-07-01. It has received 9424 citations till now.
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TL;DR: Evaluating the broadest toxic effect of some synthetic additives of colorants and/or flavors on different body organs and metabolic aspects in rats found all food colorants mixed with or without flavor additives induced a significant decrease in body weight, hemoglobin concentration and red blood cell count.
Abstract: The objective of the present work was to evaluate the broadest toxic effect of some synthetic additives of colorants and/or flavors on different body organs and metabolic aspects in rats. A number of chemical food color and flavor additives are routinely added during processing to improve the aesthetic appearance of the dietary items. However, many of them are toxic after prolonged use. In this experiment, a total of 100 male albino rats of Spargue Dawley strain were divided into 10 groups: G(1) was fed basal diet and served as control, G(2): basal diet + Brilliant blue (blue dye, No. 2, 124 mg/kg diet), G(3): basal diet + carmoisine (red dye, No. 3, 70 mg/kg diet), G(4): basal diet + tartrazine (yellow dye, FD & C yellow No. 5, 75 mg/kg diet), G(5): basal diet + trans-anethole (4.5 g/kg diet) G(6): basal diet + propylene glycol (0.25 g/kg diet), G(7): basal diet + vanillin(1.25 g/kg diet), G(8): basal diet + Brilliant blue + propylene glycol, G(9): basal diet + carmoisine + trans-anethole, G(10): basal diet + tartrazine + vanillin for 42 successive days. All food colorants mixed with or without flavor additives induced a significant decrease in body weight, hemoglobin concentration and red blood cell count. Also there was a significant decrease in reduced glutathione content; glutathione-S-transferase and superoxide dismutase activities in both blood and liver compared to control group. On the other hand, a significant increase in serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase activities, bilirubin, urea, creatinine, total protein and albumin were observed in all test groups when compared to control group. Finally, it is advisable to limit the uses of these food colorants and/or food flavor additives especially those used by children.
98 citations
Cites methods from "A colorimetric method for the deter..."
...Serum activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were estimated by quantitative enzymatic colorimetric, end point method using kits developed by Biodiagnostic Company, Giza, Egypt, according to Reitman and Frankel (1957)....
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TL;DR: An alcoholic extract of whole plant Boerhaavia diffusa given orally exhibited hepatoprotective activity against experimentally induced carbon tetrachloride hepatotoxicity in rats and mice.
98 citations
TL;DR: Results indicated that plumbagin enhanced GLUT4 translocation and contributed to glucose homeostasis and could be further probed for use as a drug to treat diabetes.
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TL;DR: There was an inverse relationship between growth and Cu concentration and there was no correlation between growth rate and RNA:DNA ratio in the liver and muscle, and Cu exposure increased GOT and GPT serum concentrations with increasing time and dose.
98 citations
TL;DR: No pseudocyst formations or acute haemorrhagic pancreatitis occurred in this series of stings of the scorpion of Trinidad, the Tityus trinitatis.
Abstract: Over a two-month period 30 patients were admitted to hospital following stings of the scorpion of Trinidad, the Tityus trinitatis. In 24 cases acute pancreatitis developed soon after the sting, but in nine of these no abdominal pain occurred. All the patients made an uneventful recovery. Although such complications have been reported no pseudocyst formations or acute haemorrhagic pancreatitis occurred in this series.
98 citations