A Compendium of Potential Biomarkers of Pancreatic Cancer
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Cites background from "A Compendium of Potential Biomarker..."
...The list of genes abnormally overexpressed in pancreatic cancer is large, and includes proteins such as mesothelin, trefoil factor 1, prostate stem cell antigen, claudin 4, and several of the S100-related proteins.(92) These overexpressed genes are potentially clinically important for 2 reasons....
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...that are secreted, could form the basis for a clinical test for the detection of pancreatic cancer.(92) Of interest, Wang et al have suggested that one could integrate our understanding of the genes that are genetically altered with those that are expressed in pancreatic cancer to develop a test that detects mutant proteins shed by the cancers....
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Additional excerpts
...A commonly successful technique has been initial discovery in pooled samples to identify dominant effects and then verification and exploration of biodiversity in follow-up studies on individual sample...
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References
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"A Compendium of Potential Biomarker..." refers background in this paper
...The role of the stromal component in pancreatic cancer progression is also being investigated, and recent reports provide experimental evidence to show the effect of the tumor microenvironment in promoting pancreatic cancers [14]....
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991 citations
"A Compendium of Potential Biomarker..." refers background in this paper
...Pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms are well-defined precursor lesions of invasive pancreatic cancer [6]....
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644 citations