Figure 1. Structures of the α-conotoxin Vc1.1 and the extracellular domain of the α9α10 nAChR. (A) The NMR-derived distance and angle restrained (PDB code: 2H8S) structure of Vc1.1. The backbone and side chains of Vc1.1 are shown in cartoon and stick representations, respectively. α-Conotoxin Vc1.1 is a 16-amino acid peptide and has two disulfide bonds and an amidated C-terminus (represented by “#” in the sequence). (B) The extracellular ligand binding domain of the α9α10 nAChR. The α-conotoxin binding site is putatively located at the cleft between the α10(+) and α9(−) components or α9(+) and α9(−)components (grey cloud).
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