A Criterion for Reliability of Formation Constants of Weak Complexes
01 Jan 1965-Journal of the American Chemical Society (American Chemical Society)-Vol. 87, Iss: 2, pp 167-170
About: This article is published in Journal of the American Chemical Society.The article was published on 1965-01-01. It has received 193 citations till now. The article focuses on the topics: Reliability (statistics).
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TL;DR: In this paper, the authors discuss the contributions provided by synthetic cyclophanes as hosts to the understanding of molecular complexation of neutral organic guest molecules in aqueous and organic solvents.
Abstract: Since the discovery of the crown ethers by Pedersen twenty years ago, the chemistry of synthetic hosts for the selective complexation of organic and inorganic guests has seen an extraordinarily rapid development. This article discusses in particular the contributions provided by synthetic cyclophanes as hosts to the understanding of molecular complexation of neutral organic guest molecules in aqueous and organic solvents. In aqueous solution, cyclophanes form stoichiometric complexes with neutral aromatic guests which can approach enzyme-substrate complexes in their stability. Efficient molecular complexation is also observed in organic environments. Here, as a result of large solvation effects, the strength of complexation is strongly dependent on the nature of the organic solvent. Electron donor-acceptor interactions can contribute significantly to the stability of complexes formed between cyclophane hosts and aromatic guests. Force-field calculations together with computer graphics are powerful tools in the design of water-soluble, optically active hosts for chiral recognition of complexed racemic guests. Simple and selective functionalization of the cyclophane framework leads to stable, bioorganic catalysts. Like enzymes, these catalysts bind their substrates in a rapid equilibrium prior to the reaction steps. As a perspective, some fascinating research objectives in the field of molecular recognition and catalysis which can be targeted with designed cyclophane hosts are shown.
353 citations
TL;DR: In this article, a layer-by-layer adaption method for multilayer assemblies of polymeric materials was proposed. But this method was applied to poly[2-(9-carbazolyl)ethyl methacrylate.
Abstract: This paper is concerned with a novel layer-by-layer adsorption method for preparing multilayer assemblies of polymeric materials. We employed two kinds polymers, poly[2-(9-carbazolyl)ethyl methacry...
287 citations
TL;DR: In this paper, a charge-transfer origin (λCT) analysis of the colored solutions revealed their charge transfer origin and provided quantitative information of the intermolecular association in the form of the KDA and eCT values for the formation and visualization, respectively, of different [D,A] complexes.
Abstract: Molecular association of various aromatic hydrocarbons (D, including sterically hindered donors) with a representative group of diverse acceptors (A = quinone, trinitrobenzene, tetracyanoethylene, tropylium, tetranitromethane, and nitrosonium) is visually apparent in solution by the spontaneous appearance of distinctive colors. Spectral (UV−vis) analyses of the colored solutions reveal their charge-transfer origin (λCT), and they provide quantitative information of the intermolecular association in the form of the KDA and eCT values for the formation and visualization, respectively, of different [D,A] complexes. Importantly, such measurements establish charge-transfer absorption to be a sensitive analytical tool for evaluating the steric inhibition of donor−acceptor association. For example, the steric differences among various hindered aromatic donors in their association with quinone are readily dramatized in their distinctive charge-transfer (color) absorptions and verified by X-ray crystallography of ...
259 citations
TL;DR: It is demonstrated that the mucopolysaccharide acts as a catalyst in this process and is able to initiate multiple rounds of enzyme-inhibitor complex formation and be able to accelerate the thrombin-antithrombin interaction.
211 citations