A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease
Sophie Hue,Jean-Jacques Mention,Renato C. Monteiro,Shao Ling Zhang,Christophe Cellier,Jacques Schmitz,Virginie Verkarre,Nassima Fodil,Seiamak Bahram,Nadine Cerf-Bensussan,Sophie Caillat-Zucman +10 more
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TLDR
It is shown that MICA is strongly expressed at epithelial cell surface in patients with active disease and is induced by gliadin or its p31-49 derived peptide upon in vitro challenge, which supports a key role for MIC/NKG2D in the activation of intraepithelial immunity in response to danger.About:
This article is published in Immunity.The article was published on 2004-09-01 and is currently open access. It has received 694 citations till now. The article focuses on the topics: NKG2D & Natural killer cell.read more
Citations
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The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial.
Nicholas R. Anthonisen,Melissa Skeans,Robert A. Wise,Jure Manfreda,Richard E. Kanner,John E. Connett +5 more
TL;DR: The smoking cessation program was associated with cumulative reduced decline in lung function (FEV1) that was largest in participants who stopped smoking early in the study; inhaled ipratropium produced a small noncumulative increase in FEV1 that disappeared when the drug was withdrawn.
Journal ArticleDOI
Immunity, Inflammation, and Allergy in the Gut
TL;DR: In both mouse and man, mutations in genes that control innate immune recognition, adaptive immunity, and epithelial permeability are all associated with gut inflammation, which suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy.
Journal ArticleDOI
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner
François Ghiringhelli,Cédric Ménard,Magali Terme,Caroline Flament,Julien Taieb,Nathalie Chaput,Pierre E. Puig,Sophie Novault,Bernard Escudier,Eric Vivier,A. Lecesne,Caroline Robert,Jean-Yves Blay,Jacky Bernard,Sophie Caillat-Zucman,Antônio C. Freitas,T. Tursz,Orianne Wagner-Ballon,Claude Capron,William Vainchencker,François Martin,Laurence Zitvogel +21 more
TL;DR: A role for T reg cells in blunting the NK cell arm of the innate immune system is supported in controlling innate antitumor immunity through inhibition of NK cell effector functions and down-regulated NKG2D receptors on theNK cell surface.
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American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease
TL;DR: This technical review addresses the state of evidence for celiac disease epidemiology, detection by serologic testing, diagnosis by biopsy, treatment, and outcome.
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Regulation of Ligands for the NKG2D Activating Receptor
TL;DR: The numerous pathways that have been implicated in the regulation of NKG2D ligands are reviewed, the pathologic states in which those pathways are likely to act are discussed, and the findings are synthesized into general schemes of NKD ligand regulation in NK cell responses to cancer and infection.
References
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Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
TL;DR: An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.
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Identification of tissue transglutaminase as the autoantigen of celiac disease
Walburga Dieterich,Tobias Ehnis,Michael Bauer,Peter Donner,Umberto Volta,Ernst Otto Riecken,Detlef Schuppan +6 more
TL;DR: Tissue transglutaminase is identified as the unknown endomysial autoantigen of celiac disease, and gliadin is a preferred substrate for this enzyme, giving rise to novel antigenic epitopes.
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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
TL;DR: It is shown that binding of MIC induces endocytosis and degradation of NKG2D, a mode of T-cell silencing that may promote tumour immune evasion and, by inference, compromise host resistance to infections.
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Structural Basis for Gluten Intolerance in Celiac Sprue
Lu Shan,Øyvind Molberg,Isabelle Parrot,Felix Hausch,Ferda Filiz,Gary M. Gray,Ludvig M. Sollid,Chaitan Khosla +7 more
TL;DR: A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients, and could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for CeliacSprue.