A fiber-optic chemical sensor based on surface plasmon resonance
TL;DR: In this paper, a fiber-optic chemical sensor is presented which utilizes surface plasmon resonance excitation, which is fabricated by removing a section of the fiber cladding and symmetrically depositing a thin layer of highly reflecting metal onto the fiber core.
Abstract: A fiber-optic chemical sensor is presented which utilizes surface plasmon resonance excitation The sensing element of the fiber has been fabricated by removing a section of the fiber cladding and symmetrically depositing a thin layer of highly reflecting metal onto the fiber core A white-light source is used to introduce a range of wavelengths into the fiber optic Changes in the sensed parameters (eg, bulk refractive index, film thinkness and film refractive index) are determined by measuring the transmitted spectral-intensity distribution Experimental results of the sensitivity and the dynamic range in the measurement of the refractive indices of aqueous solutions are in agreement with the theoretical model of the sensor
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TL;DR: Main application areas are outlined and examples of applications of SPR sensor technology are presented and future prospects of SPR technology are discussed.
Abstract: Since the first application of the surface plasmon resonance (SPR) phenomenon for sensing almost two decades ago, this method has made great strides both in terms of instrumentation development and applications. SPR sensor technology has been commercialized and SPR biosensors have become a central tool for characterizing and quantifying biomolecular interactions. This paper attempts to review the major developments in SPR technology. Main application areas are outlined and examples of applications of SPR sensor technology are presented. Future prospects of SPR sensor technology are discussed.
5,127 citations
Cites methods from "A fiber-optic chemical sensor based..."
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...The use of optical fibers for SPR sensing was first proposed by Jorgenson and Yee [21]....
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...measurement of the resonant momentum of the optical wave including angular [18,19] and wavelength interrogation of SPR [20–22]....
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TL;DR: This work presents a meta-analysis of the literature on food quality and safety analysis and its applications in the context of veterinary drugs and drugs and drug-Induced Antibodies, which focuses on the role of canine coronavirus in the veterinary industry.
Abstract: 5.1. Detection Formats 475 5.2. Food Quality and Safety Analysis 477 5.2.1. Pathogens 477 5.2.2. Toxins 479 5.2.3. Veterinary Drugs 479 5.2.4. Vitamins 480 5.2.5. Hormones 480 5.2.6. Diagnostic Antibodies 480 5.2.7. Allergens 481 5.2.8. Proteins 481 5.2.9. Chemical Contaminants 481 5.3. Medical Diagnostics 481 5.3.1. Cancer Markers 481 5.3.2. Antibodies against Viral Pathogens 482 5.3.3. Drugs and Drug-Induced Antibodies 483 5.3.4. Hormones 483 5.3.5. Allergy Markers 483 5.3.6. Heart Attack Markers 484 5.3.7. Other Molecular Biomarkers 484 5.4. Environmental Monitoring 484 5.4.1. Pesticides 484 5.4.2. 2,4,6-Trinitrotoluene (TNT) 485 5.4.3. Aromatic Hydrocarbons 485 5.4.4. Heavy Metals 485 5.4.5. Phenols 485 5.4.6. Polychlorinated Biphenyls 487 5.4.7. Dioxins 487 5.5. Summary 488 6. Conclusions 489 7. Abbreviations 489 8. Acknowledgment 489 9. References 489
3,698 citations
TL;DR: This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms, and focuses on the optical biosENSors that utilize the refractive index change as the sensing transduction signal.
2,060 citations
TL;DR: In this article, a simple but quantitative mathematical formalism for interpretation of surface plasmon resonance (SPR) signals from adsorbed films of a wide variety of structures is presented.
Abstract: A simple but quantitative mathematical formalism for interpretation of surface plasmon resonance (SPR) signals from adsorbed films of a wide variety of structures is presented. It can be used to estimate adsorbed film thicknesses, surface coverages, or surface concentrations from the SPR response over the entire range of film thicknesses without relying on calibration curves of response versus known thicknesses or surface concentrations. This formalism is compared to more complex optical simulations. It is further tested by (1) calibrating the response of two SPR spectrometers to changes in bulk index of refraction, (2) using these calibrations with this formalism to predict responses to several well-characterized adlayer structures (alkanethiolates and serum albumin on gold, propylamine on COOH-functionalized gold), and then (3) comparing these predictions to measured SPR responses. Methods for estimating the refractive index of the adlayer material are also discussed. Detection limits in both bulk and a...
986 citations
TL;DR: A detailed mechanism of the surface plasmon resonance (SPR) technique for sensing purposes has been discussed in this paper, where different new techniques and models in this area that have been introduced are discussed in quite a detail.
Abstract: Since the introduction of optical fiber technology in the field of sensor based on the technique of surface plasmon resonance (SPR), fiber-optic SPR sensors have witnessed a lot of advancements. This paper reports on the past, present, and future scope of fiber-optic SPR sensors in the field of sensing of different chemical, physical, and biochemical parameters. A detailed mechanism of the SPR technique for sensing purposes has been discussed. Different new techniques and models in this area that have been introduced are discussed in quite a detail. We have tried to put the different advancements in the order of their chronological evolution. The content of the review article may be of great importance for the research community who are to take the field of fiber-optic SPR sensors as its research endeavors.
824 citations
Cites background from "A fiber-optic chemical sensor based..."
...mental work on a fiber-optic chemical sensor based on SPR by fabricating the probe on a highly multimoded optical fiber and using a white light source instead of a monochromatic one [15]....
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References
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TL;DR: In this paper, the index of refraction of optical quality fused silica (SiO2) was determined for 60 wavelengths from 0.21 to 3.71 μ at 20°C.
Abstract: The index of refraction of optical quality fused silica (SiO2) was determined for 60 wavelengths from 0.21 to 3.71 μ at 20°C. The dispersion equation n2-1=0.6961663λ2λ2-(0.0684043)2+0.4079426λ2λ2-(0.1162414)2+0.8974794λ2λ2-(9.896161)2.where λ is expressed in microns was found to yield an absolute residual of 10.5×10−6. The variation in index between 12 specimens was determined. Dispersive properties of the material and thermal coefficient of index are graphically presented. A comparison with previous NBS index data is discussed.
3,382 citations
TL;DR: In this paper, it has been shown that the non-radiative mode excited by light can also radiate under certain conditions if they are excited by electrons (grazing incidence of electrons on a rough surface or at normal incidence on a grating).
Abstract: There are two modes of surface plasma waves: 1) Non-radiative modes with phase velocities Cü/k smaller than the velocity of light c. They cannot decay into photons in general. 2) Radiative modes with (o/k > c which couple directly with photons 1. The following paper is concerned with the excitation of these modes by light and their decay into photons. It has been shown that the radiative mode on thin silverand potassium-films can be excited by light and that the mode reradiates light almost into all directions with an intensity maximum at the plasma frequency cOp 2. It had been further observed that the non-radiative modes radiate under certain conditions if they are excited by electrons (grazing incidence of electrons on . a rough surface3 or at normal incidence on a grating 4) . The mechanism of this emission is in these cases always the same: The \"wave vector\" of the roughness of the surface or its irregularity changes the plasmon wave vector k so that a) in the case of the radiative mode light emission is found in directions in addition to that of reflexion and transmission, b) in the case of the non-radiative mode its wave vector is reduced so that the condition /c0, the wave vector of the inhomogeneous wave is (co/c) • Vsq' sin 0O (fq = 2.16 for quartz) and thus can excite a non radiative mode on the boundary of the prism for j/fq sin 0O > 1 or 90° > @o > 43°. If one vaporises a silver film directly on the quartz surface the inhomogeneous light wave penetrates into the silver film and excites a nonradiative mode on the boundary silver/air. The excitation will be highest for those frequencies which fulfill the dispersion relation of these surface plasmons.
2,790 citations
TL;DR: The surface plasmon resonance (SPR) is a new optical technique in the field of chemical sensing as discussed by the authors, which can be used for gas detection, together with results from exploratory experiments with relevance to biosensing.
2,243 citations
TL;DR: A new optical chemical sensor was developed for chemical sensing based on light-excited surface plasmon measurement, which can be compact and simple, because of the absence of mechanical moving parts, by using multichannel angular light intensity detection with a photodiode array and a Fourier transform optical setup.
Abstract: A new optical chemical sensor was developed for chemical sensing based on light-excited surface plasmon measurement. Concentration of the chemical species is found in liquid or gas without the help of a reagent but by measuring the resonance condition of the surface plasmon on the sensing metal surface. The resonance condition is given by the dielectric constant of the sample faced on the metal. The developed sensor can be compact and simple, because of the absence of mechanical moving parts, by using multichannel angular light intensity detection with a photodiode array and a Fourier transform optical setup. Experimental results are shown for measurement of ethanol concentration in water. The detection limit for ethanol in water was 10(-4) wt./wt. by the experiments with the developed system.
338 citations
TL;DR: In this article, the results obtained using the avidin-biotin binding pair as a model sysem and the α-feto protein antibody-antigen system demonstrate the concentration-dependent response at around the nanomolar concentration range within a response time of a few minutes.
127 citations