A fibril reinforced nonhomogeneous poroelastic model for articular cartilage: inhomogeneous response in unconfined compression.
TL;DR: The model suggests mechanical behaviors significantly different from those revealed by homogeneous models: not only the depth variations of the strains which are expected by qualitative analyses, but also the relaxation-time dependence of the axial strain which is normally not expected in a relaxation test.
About: This article is published in Journal of Biomechanics.The article was published on 2000-12-01. It has received 169 citations till now. The article focuses on the topics: Poromechanics.
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TL;DR: 3D-deposited scaffolds seeded with bovine articular chondrocytes supported a homogeneous cell distribution and subsequent cartilage-like tissue formation following in vitro culture as well as subcutaneous implantation in nude mice.
582 citations
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TL;DR: The hypothesis that the temporal variation of the frictional coefficient correlates negatively with the interstitial fluid load support and that consequently interstitialfluid load support is a primary mechanism regulating thefrictional response in articular cartilage is supported.
295 citations
Cites background from "A fibril reinforced nonhomogeneous ..."
...Since cartilage mechanical properties are inhomogeneous through the depth [1,20,37,47] the interstitial fluid pressurization will be depth-dependent as confirmed both experimentally [34] and theoretically [21,22]....
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TL;DR: The present model concludes that the local stresses and strains in the articular cartilage are highly influenced by the local morphology of the collagen-fibril network, which is likely to be one of the earliest signs of OA cartilage degeneration.
293 citations
Cites background from "A fibril reinforced nonhomogeneous ..."
...The initial void ratio was depth dependent (Li et al., 2000), as...
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TL;DR: The newly developed fibril-reinforced poroviscoelastic swelling (FPVES) model for articular cartilage can simultaneously account for the reaction force during swelling, confined compression, indentation and unconfined compression as well as the lateral deformation during unconfining compression.
278 citations
TL;DR: It is concluded that the compression-tension nonlinearity of the tissue is needed to capture realistically the mechanical behavior of normal and degenerated articular cartilage in unconfined compression.
275 citations
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2,376 citations
"A fibril reinforced nonhomogeneous ..." refers methods in this paper
...A "bril-network was introduced into the biphasic model (Mow et al., 1980) in an e!ort to simulate the strong load relaxation in uncon"ned tests (Soulhat et al....
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TL;DR: The delineation of the depth‐dependent modulus provides a basis for detailed study of the relationship between the composition, structure, and function of cartilage in such processes as aging, repair, and degeneration.
626 citations
TL;DR: The flow‐independent (intrinsic) tensile modulus of the extracellular matrix of human knee joint cartilage has been measured for normal, fibrillated, and osteoarthritic (removed from total knee joint replacements) cartilage and correlates strongly with the collagen/proteoglycan ratio.
498 citations
TL;DR: The hypothesis that deformation of chondrocytes or a change in their volume may occur during in vivo joint loading and may have a role in the mechanical signal transduction pathway of articular cartilage is supported.
494 citations