A genetic model for colorectal tumorigenesis
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...In most cases, however, a single mutation is insufficient and many cancers require at least 4-5 mutations (Fearon and Vogelstein, 1990; Hanahan and Weinberg, 2000)....
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"A genetic model for colorectal tumo..." refers background in this paper
...Although the process of adenoma progression is actually a continuum, presumably resulting from successive waves of clonal expansion (Nowell, 1976) three discrete stages of adenoma formation are depicted in Figure 3....
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2,708 citations
"A genetic model for colorectal tumo..." refers background in this paper
...Similar mutations have been observed in the remaining ~53 alleles of lung, breast, and brain tumors with chromosome 17p losses (Nigro et al., 1989; Takahashi et al., 1989; lggo et al., 1990)....
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...Further support for this model of ~53 mutation and its phenotypic effect in the presence of a wild-type allele in human tumor cells is provided by the discovery of at least one colorectal tumor demonstrating the postulated intermediate step (Nigro et al., 1989)....
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...Furthermore, mutations resulting in amino acid substitutions in the ~53 gene product have been observed in the remaining ~53 alleles of several colorectal cancers that had concomitant allelic losses of chromosome 17p (Baker et al., 1989; Nigro et al., 1989)....
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2,081 citations
"A genetic model for colorectal tumo..." refers background in this paper
...The common region of loss on chromosome 17p in colorectal tumors has been identified and contains the ~53 gene (Baker et al., 1989)....
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...Furthermore, mutations resulting in amino acid substitutions in the ~53 gene product have been observed in the remaining ~53 alleles of several colorectal cancers that had concomitant allelic losses of chromosome 17p (Baker et al., 1989; Nigro et al., 1989)....
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1,951 citations