A global reference for human genetic variation.
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...Indeed, population structure analyses of the 1000 Genomes samples suggest that Peruvians have the largest amount of Native American ancestry (Auton et al. 2015) and show a bottleneck with a lack of recent population growth, which could explain this pattern....
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...We then apply these statistics to real human genomic data from phase 3 of the 1000 Genomes Project (Auton et al. 2015), to detect AI in human populations, and find candidate genes....
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...We used each of the non-African panels in the 1000 Genomes Project phase 3 data (Auton et al. 2015) as the “target” panel (B), and chose the outgroup panel (A) to be the combination of all African populations (YRI, LWK, GWD, MSL, and ESN), excluding admixed African-Americans....
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...Candidate Regions for Adaptive Introgression To identify adaptively introgressed regions of the genome, we computed UA;B;C;Dðw; x; y; zÞ and Q95A;B;C;Dðw; y; zÞ in 40 kb nonoverlapping windows along the genome, using the Archaic Adaptive Introgression in Present-Day Human Populations . doi:10.1093/molbev/msw216 MBE low-coverage sequencing data from phase 3 of the 1000 Genomes Project (Auton et al. 2015)....
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...By scanning the present-day human genomes from phase 3 of the 1000 Genomes Project (Auton et al. 2015) using these and other summary statistics, we were able to recapitulate previous AI findings (like the TLR [Dannemann et al. 2016; Deschamps et al. 2016] and OAS regions [Mendez et al. 2013]) as well as identify new candidate regions for AI in Eurasia (like the LIPA gene and the FAP/IFIH1 region)....
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162 citations
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162 citations
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