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Journal ArticleDOI

A green process for the preparation of 11-{4-[2-(2-hydroxyethoxy) ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine

01 Jan 2008-Journal of The Serbian Chemical Society (National Library of Serbia)-Vol. 73, Iss: 4, pp 385-391
Abstract: A green process for the synthesis of 11-{4-[2-(2-hydroxyethoxy)ethyl]- 1-piperazinyl}dibenzo[b,f][1,4]thiazepine by the reaction of 11-(1-piperazinyl) dibenzo[b,f][1,4]thiazepine or its dihydrochloride salt with 2-(2-chloroethoxy) ethanol in the presence of an inorganic base and water is reported (conversion 99.9 % in a short time and without any impurities). The metal halides and phase transfer catalyst increase the rate of reaction, especially in water as the solvent.

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Topics: Thiazepine (58%)
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Journal ArticleDOI
Simer Preet1, Damanjt Singh Cannoo1Institutions (1)
TL;DR: A facile and highly efficient one-pot synthesis of novel thiazepine and benzothiazepine derivatives was established by ring expansion by using a greener methodology and the synthesized compounds show fluorescence and also antioxidant activity.

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Abstract: A facile and highly efficient one-pot synthesis of novel thiazepine and benzothiazepine derivatives was established by ring expansion. With a greener methodology (ultrasonication), a polysubstituted ring system with the thiazepine core moiety can be easily synthesized from simple and easily available reactants in good yields. Moreover, the synthesized compounds show fluorescence and also antioxidant activity.

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6 citations


Journal ArticleDOI
Chen Li1, Min-Tong Ge1, Liang Bai1, Ai-Bao Xia1  +2 moreInstitutions (1)
Abstract: An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy. The present methodology features base-free conditions and broad substrate scope, with water being the only by-product. Moreover, this protocol has been applied to the synthesis of the pharmaceutical drug Quetiapine.

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1 citations


Journal Article
Abstract: Dibenzothiazepine, a conjugated heterocyclic ring systems reported for their wide spectrum of pharmacological activity especially for its psychotherapeutic activities. Successful introduction of quetiapine, tianeptine, clotiapine for antipsychotic activity along with its evidence for other biological activity proved potential of dibenzothiazepine moiety. Subsequently dibenzodiazepine were highlighted as important biologically active scaffolds. The discovery of quetiapine fumarate as psychotropic agents attracted much attention worldwide. The current review article focuses on pharmacological and synthetic profile of dibenzothiazepine. This article mainly outlines some structural modifications done on dibenzothiazepine to offer newer derivatives with potential biological activity.

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Book ChapterDOI
27 Oct 2010-

References
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Journal ArticleDOI
01 Sep 1993-Chemical Reviews
Abstract: Carbon-carbon bond formation is the essence of organic synthesis. Although the well-known Kolbe synthesis was discovered in 1849Ia (the first observation wasmadein 1834byFaraday),'bformorethanacentury, carbon-carbon bond formation in aqueous media has been limited mainly to electrochemical processes and aldol condensation reactions. This is in contrast to the many enzymatic processes that by necessity must occur in an aqueous environment. In the last decade, there has been increasing recognition that organic reactions carried out in aqueous media may offer advantages over those occurring in organic solvents. For example, protection and deprotection processes in organic synthesis can possibly be simplified. This review will survey this area, concentrating mainly on the last decade. The review is organized into three main portions: nonorganometallic reactions, organometallic reactions, and transition-metal-catalyzed organic reactions in aqueous media. The conventional aldol-type and related reactions, stabilized carbanion alkylation reactions, electrochemical reactions as well as bioorganic reactions involving aqueous media and leading to carbon-carbon bond formation will not be included.

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1,114 citations


Journal ArticleDOI

1,021 citations


Journal ArticleDOI
Chao-Jun Li1Institutions (1)
15 Apr 1996-Tetrahedron

415 citations


Journal ArticleDOI
Liang Chen1, Chao-Jun Li1Institutions (1)
31 Jul 2004-Organic Letters
TL;DR: A highly effective direct coupling of acid chloride with terminal alkynes catalyzed by PdCl(2)(PPh(3))(2)/CuI together with a catalytic amount of sodium lauryl sulfate as the surfactant and K(2)CO(3) as the base provided ynones in high yields in water.

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Abstract: A highly effective direct coupling of acid chloride with terminal alkynes catalyzed by PdCl2(PPh3)2/CuI together with a catalytic amount of sodium lauryl sulfate as the surfactant and K2CO3 as the base provided ynones in high yields in water.

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119 citations



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