Book ChapterDOI
A history of the kidney in plasma cell disorders.
David P. Steensma,Robert A. Kyle +1 more
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TLDR
Historical understanding of the kidney in plasma cell disorders reflects developments in understanding ofThe anatomy and physiology of the kidneys in health and in disease.Abstract:
Background: The kidneys are commonly injured in plasma cell dyscrasias. Methods:
We reviewed the pertinent medical literature related to the historical development of clinical
nephrology and diagnosread more
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Journal ArticleDOI
The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.
Nelson Leung,Frank Bridoux,Vecihi Batuman,Aristeidis Chaidos,Paul Cockwell,Vivette D. D'Agati,Angela Dispenzieri,Fernando C. Fervenza,Jean Paul Fermand,Simon D. J. Gibbs,Julian D. Gillmore,Guillermo A. Herrera,Arnaud Jaccard,Dragan Jevremovic,Efstathios Kastritis,Vishal Kukreti,Robert A. Kyle,Helen J. Lachmann,Christopher P. Larsen,Heinz Ludwig,Glen S. Markowitz,Giampaolo Merlini,Peter Mollee,Maria M. Picken,Vincent Rajkumar,Virginie Royal,Paul W. Sanders,Sanjeev Sethi,Christopher P. Venner,Peter M. Voorhees,Ashutosh D. Wechalekar,Brendan M. Weiss,Samih H. Nasr +32 more
TL;DR: The IKMG redefines MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined haematological criteria for treatment of a specific malignancy.
Journal ArticleDOI
Laboratory testing in monoclonal gammopathy of renal significance (MGRS).
TL;DR: Using the time of flight method, the use of mass spectrometry of serum samples has been shown to dramatically increase the sensitivity of M-protein detection and in another technique, oligomeric LCs are identified on urinary exosomes amplifying the specificity for the nephrotoxic M- protein.
Book ChapterDOI
History of Multiple Myeloma
Robert A. Kyle,David P. Steensma +1 more
TL;DR: The authors have reviewed the treatment of multiple myeloma including the novel agents, thalidomide, bortezomib and lenalidomice, and the recognised plasma cells and subsequently their product, a monoclonal protein.
Journal ArticleDOI
New aspects on the pathogenesis of renal disorders related to monoclonal gammopathies.
TL;DR: This review summarizes the existing literature in the pathobiology of multiple myeloma, and the pathological properties of the M-proteins, focusing on the mechanisms of the renal manifestations related to these abnormal proteins, especially glomerular injury.
Journal ArticleDOI
Light Chain Cast Nephropathy: Practical Considerations in the Management of Myeloma Kidney-What We Know and What the Future May Hold
TL;DR: FLC plays a key role in the development and resolution of LCCN and future therapies will aim to rapidly reduce its concentration or interrupt its interaction with Tamm-Horsfall protein.
References
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Journal ArticleDOI
Review: History of the Amyloid Fibril
Jean D. Sipe,Alan S. Cohen +1 more
TL;DR: Chemical and physical definition of the fibrils in tissues will be needed to relate the in vitro properties of amyloid protein fibril formation in vivo to the pathogenesis ofAmyloid fibrillar formation in vitro.
Journal ArticleDOI
Clinical features of sudden obstruction of the coronary arteries
TL;DR: In Germany Cohnheim supported the views of Hyrtl and Henle as to lack of considerable anastomosis, and as late as 1881 lent the influence of his name to the doctrine that the coronary arteries were end-arteries.
Journal ArticleDOI
Electron microscopic observations on a fibrous component in amyloid of diverse origins.
Alan S. Cohen,Evan Calkins +1 more
TL;DR: The precise definition of the amyloid protein has, however, been hampered by its insolubility in organic solvents.
Journal ArticleDOI
Incipient myelomatosis or «essential« hyperglobulinemia with fibrinogenopenia — a new syndrome?
Journal ArticleDOI
Aspiration biopsy of the kidney.
Poul Iversen,Claus Brun +1 more
TL;DR: It is considered that continued studies of material removed by aspiration biopsy of the kidney may contribute materially to solution of the pathophysiologic problems of the heterogeneous group of renal diseases generally termed "lower nephron nephrosis".
Related Papers (5)
Urinary Albumin Excretion Patterns of Patients with Cast Nephropathy and Other Monoclonal Gammopathy–Related Kidney Diseases
Nelson Leung,Morie A. Gertz,Robert A. Kyle,Fernando C. Fervenza,Maria V. Irazabal,Alfonso Eirin,Shaji Kumar,Stephen S. Cha,S. Vincent Rajkumar,Martha Q. Lacy,Steve R. Zeldenrust,Francis K. Buadi,Suzanne R. Hayman,Samih H. Nasr,Sanjeev Sethi,Marina Ramirez-Alvarado,Thomas E. Witzig,Sandra M. Herrmann,Angela Dispenzieri +18 more
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