A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
Yoshihiro Kashiwaya,Christian Bergman,Jong Hwan Lee,Ruiqian Wan,M. Todd King,Mohamed R. Mughal,Eitan Okun,Kieran Clarke,Mark P. Mattson,Richard L. Veech +9 more
Reads0
Chats0
TLDR
A novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model by reducing levels of hyperphosphorylated tau deposition in the regions of the hippocampus, amygdala, and cortex.About:
This article is published in Neurobiology of Aging.The article was published on 2013-06-01 and is currently open access. It has received 261 citations till now. The article focuses on the topics: Ketogenic diet & Alzheimer's disease.read more
Citations
More filters
Journal ArticleDOI
Fasting: Molecular Mechanisms and Clinical Applications
TL;DR: In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis.
Journal ArticleDOI
Ketone bodies as signaling metabolites
John C. Newman,Eric Verdin +1 more
TL;DR: Findings support a model in whichβOHB functions to link the environment, in this case the diet, and gene expression via chromatin modifications, and the implications of HDAC inhibition by the ketone body βOHB in the modulation of metabolism and in diseases of aging.
Journal ArticleDOI
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
TL;DR: An overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health is provided.
Journal ArticleDOI
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Peisu Zhang,Yuki Kishimoto,Ioannis Grammatikakis,Kamalvishnu P. Gottimukkala,Roy G. Cutler,Shiliang Zhang,Kotb Abdelmohsen,Vilhelm A. Bohr,Jyoti Misra Sen,Jyoti Misra Sen,Myriam Gorospe,Mark P. Mattson,Mark P. Mattson +12 more
TL;DR: A role for Aβ-induced OPC cell senescence in neuroinflammation and cognitive deficits in AD is suggested, and a potential therapeutic benefit of senolytic treatments is suggested.
Journal ArticleDOI
Brain metabolism in health, aging, and neurodegeneration
TL;DR: It is suggested that lifestyles that include intermittent bioenergetic challenges, most notably exercise and dietary energy restriction, can increase the likelihood that the brain will function optimally and in the absence of disease throughout life.
References
More filters
Journal ArticleDOI
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
TL;DR: The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Journal ArticleDOI
AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
TL;DR: Two new diets may prove to be a better choice than AIN-76A for long-term as well as short-term studies with laboratory rodents because of a better balance of essential nutrients.
Journal ArticleDOI
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction
Salvatore Oddo,Antonella Caccamo,Jason D. Shepherd,M. Paul Murphy,Todd E. Golde,Rakez Kayed,Raju Metherate,Mark P. Mattson,Yama Akbari,Frank M. LaFerla +9 more
TL;DR: The recapitulation of salient features of AD in these mice clarifies the relationships between Abeta, synaptic dysfunction, and tangles and provides a valuable model for evaluating potential AD therapeutics as the impact on both lesions can be assessed.
Journal ArticleDOI
2013 Alzheimer's disease facts and figures
William Thies,Laura Bleiler +1 more
TL;DR: This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general.
Journal ArticleDOI
Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.