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A Laboratory handbook
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The article was published on 1989-01-01 and is currently open access. It has received 531 citations till now.read more
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Journal ArticleDOI
Convergent adaptation of human lactase persistence in Africa and Europe
Sarah A. Tishkoff,Floyd A. Reed,Alessia Ranciaro,Alessia Ranciaro,Benjamin F. Voight,Courtney C. Babbitt,Jesse S. Silverman,Kweli Powell,Holly M. Mortensen,Jibril Hirbo,Maha E. Osman,Muntaser E. Ibrahim,Sabah A. Omar,Godfrey Lema,Thomas B. Nyambo,Jilur Ghori,Suzannah Bumpstead,Jonathan K. Pritchard,Gregory A. Wray,Panos Deloukas +19 more
TL;DR: A genotype-phenotype association study in Tanzanians, Kenyans and Sudanese and identified three SNPs that are associated with lactase persistence and that have derived alleles that significantly enhance transcription from the LCT promoter in vitro, providing a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits.
Journal ArticleDOI
Studying protein dynamics in living cells.
TL;DR: Live cell imaging, in combination with photobleaching, energy transfer or fluorescence correlation spectroscopy are providing unprecedented insights into the movement of proteins and their interactions with cellular components.
Journal ArticleDOI
A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila.
TL;DR: A novel search algorithm is developed, used to search the Drosophila genomic sequence database, and it is shown that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes.
Journal ArticleDOI
Immunity-Related Genes and Gene Families in Anopheles gambiae
George K. Christophides,Evgeny M. Zdobnov,Carolina Barillas-Mury,Ewan Birney,Stéphanie Blandin,Claudia Blass,Paul T. Brey,Frank H. Collins,Alberto Danielli,George Dimopoulos,Charles Hetru,Ngo Thi Hoa,Jules A. Hoffmann,Stefan M. Kanzok,Ivica Letunic,Elena A. Levashina,Thanasis G. Loukeris,Gareth J Lycett,Stephan Meister,Kristin Michel,Luis F. Moita,Hans-Michael Müller,Mike A. Osta,Susan M. Paskewitz,Jean-Marc Reichhart,Andrey Rzhetsky,Laurent Troxler,Kenneth D. Vernick,Dina Vlachou,Jennifer Volz,Christian von Mering,Jiannong Xu,Liangbiao Zheng,Peer Bork,Fotis C. Kafatos +34 more
TL;DR: 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity are identified and marked diversification relative to Drosophila melanogaster is detected, confirming that sequence diversification is accompanied by specific responses to different immune challenges.
Journal ArticleDOI
Steps in the evolution of heteromorphic sex chromosomes
TL;DR: Evidence that recombination suppression occurs progressively in evolutionarily independent cases is reviewed, suggesting that selection drives loss of recombination over increasingly large regions.