Journal ArticleDOI
A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage
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TLDR
The Xenopus embryo undergoes 12 rapid synchronous cleavages followed by a period of slower asynchronous divisions more typical of somatic cells, termed the midblastula transition (MBT), which shows that at the MBT the blastomeres become motile and transcriptionally active for the first time.About:
This article is published in Cell.The article was published on 1982-10-01. It has received 1587 citations till now. The article focuses on the topics: Midblastula & Maternal to zygotic transition.read more
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Journal ArticleDOI
Stages of embryonic development of the zebrafish.
TL;DR: A series of stages for development of the embryo of the zebrafish, Danio (Brachydanio) rerio is described, providing for flexibility and continued evolution of the staging series as the authors learn more about development in this species.
Journal ArticleDOI
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
Benoit Dubertret,Paris A. Skourides,David J. Norris,David J. Norris,Vincent Noireaux,Ali H. Brivanlou,Albert Libchaber +6 more
TL;DR: C encapsulated individual nanocrystals in phospholipid block–copolymer micelles acted as in vitro fluorescent probes to hybridize to specific complementary sequences and were followed to the tadpole stage, allowing lineage-tracing experiments in embryogenesis.
Book ChapterDOI
Transcription and translation.
TL;DR: A cDNA encoding the TATA box binding protein, or TATA binding protein (TBP) subunit of transcription factor II D (TFIID), has been identified in the nematode and can substitute for vertebrate TFIID basal activity in in vitro extracts, illustrating a high degree of evolutionary conservation in the basic transcription machinery.
Journal ArticleDOI
Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
TL;DR: Eggs of the sea urchin Lytechinus pictus and oocytes of the surf clam Spisula solidissima also contain proteins that only start to be made after fertilization and are destroyed at certain points in the cell division cycle, and it is proposed to call these proteins the cyclins.
Journal ArticleDOI
Telomerase activity in human germline and embryonic tissues and cells
TL;DR: Elucidation of the regulatory pathways involved in the repression of telomerase activity during development may lead to the ability to manipulate telomere levels and explore the consequences both for cellular aging and for the survival of cancer cells.
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Journal ArticleDOI
A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription.
TL;DR: It is shown here that a plasmid containing a cloned gene coding for a yeast leucine tRNA comes under developmental control when injected into cleaving eggs, suggesting that the MBT is triggered by the DNA through titration of suppressor components present in the egg.
Journal ArticleDOI
Are snRNPs involved in splicing
TL;DR: Several lines of evidence are presented that suggest a direct involvement of snRNPs in the splicing of hnRNA molecules, including the observation that the nucleotide sequence at the 5′ end of U1 RNA exhibits extensive complementarity to those across splice junctions in hn RNA molecules.
Journal ArticleDOI
RNA synthesis during the development of Xenopus laevis, the South African clawed toad
Donald D. Brown,Elizabeth Littna +1 more
TL;DR: Methods have been described for radioactive-labeling, purification and characterization of high molecular weight RNA from eggs and embryos of Xenopus laevis, the South African clawed toad, and the following sequence of developmental events has been described.