A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Ulrike Philippar,Evanthia T. Roussos,Matthew G. Oser,Hideki Yamaguchi,Hideki Yamaguchi,Hyung-Do Kim,Silvia Giampieri,Yarong Wang,Sumanta Goswami,Sumanta Goswami,Jeffrey B. Wyckoff,Douglas A. Lauffenburger,Erik Sahai,Erik Sahai,John S. Condeelis,Frank B. Gertler +15 more
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TLDR
It is shown that Mena and Mena(INV) promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis and EGF-induced membrane protrusion of tumor cells.About:
This article is published in Developmental Cell.The article was published on 2008-12-09 and is currently open access. It has received 249 citations till now.read more
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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Immune cell promotion of metastasis
TL;DR: How tumour-infiltrating immune cells contribute to the metastatic cascade is described and potential therapeutic strategies to target these cells are discussed.
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Chemotaxis in cancer
TL;DR: This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.
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The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
TL;DR: The epithelial to mesenchymal transition converts epithelial cells into migratory and invasive cells and is a fundamental event in morphogenesis, and now constitutes a promising target for the treatment of cancer and organ-degenerative diseases.
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Modes of cancer cell invasion and the role of the microenvironment
TL;DR: Future studies will clarify how the combination of stromal network structure, tumor cell signaling and extracellular signaling cues influence cancer cell migration and metastasis.
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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
TL;DR: Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility and are an important drug target for cancer therapy.
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A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.
Jeffrey B. Wyckoff,Weigang Wang,Elaine Y. Lin,Yarong Wang,Fiona J. Pixley,E. Richard Stanley,Thomas Graf,Jeffrey W. Pollard,Jeffrey E. Segall,John S. Condeelis +9 more
TL;DR: This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophage may contribute to metastasis.
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Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors
Jeffrey B. Wyckoff,Yarong Wang,Elaine Y. Lin,Jiu Feng Li,Sumanta Goswami,E. Richard Stanley,Jeffrey E. Segall,Jeffrey W. Pollard,John S. Condeelis +8 more
TL;DR: The results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors.
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Intravital imaging of cell movement in tumours
TL;DR: Multiphoton microscopy has been developed for in vivo imaging and, using this technique, scientists are beginning to understand how invasive tumour cells move.
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Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility
James E. Bear,Tatyana Svitkina,Matthias Krause,Dorothy A. Schafer,Joseph Loureiro,Geraldine A. Strasser,Ivan V. Maly,Oleg Y. Chaga,John A. Cooper,Gary G. Borisy,Frank B. Gertler +10 more
TL;DR: It is concluded that Ena/VASP regulates cell motility by controlling the geometry of actin filament networks within lamellipodia.