α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Frans P. Nijkamp,Wybren de Jong +1 more
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TLDR
Bilateral injections of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats.About:
This article is published in European Journal of Pharmacology.The article was published on 1975-06-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Baroreceptor & Angiotensin II.read more
Citations
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Journal ArticleDOI
The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats.
S.Y. Yeh,Fu-Lian Hsu +1 more
TL;DR: In this article, the authors injected SC with a dose of 10 mg/kg (as base) of 3, 4-methylenedioxyamphetamine (MDA), or 3,4methylenedioxymethamphetamine (MDMA), 4-hydroxy-3-methoxyamphetamine, α-methyldopamine and α-methylnorepinephrine, a putative metabolite of MDMA, twice daily for either 5 or 7 consecutive doses.
Journal ArticleDOI
Metabolism of β-3,4-methylenedioxyamphetamine in the rat☆
Book ChapterDOI
Centrally induced hypotension by alpha-methyldopa and alpha-methylnoradrenaline in normotensive and renal hypertensive rats.
Nijkamp Fp,De Jong W +1 more
TL;DR: This chapter investigates the mechanism and site of action of α-methyldopa in normotensive and renal hypertensive rats, finding that the effect seems to be mediated by a site in the lower part of the brain stem.
Journal ArticleDOI
Endorphins and the hypotensive response to stimulation of alpha-receptors in the brainstem by alpha-methylnoradrenaline
Margaret A. Petty,W. De Jong +1 more
TL;DR: Results suggest that the fall in blood pressure observed after administration of alpha-methylnoradrenaline involves a beta-endorphin-like peptide, a probable site of this interaction being the n.
Journal ArticleDOI
Quantitative autoradiography of α2 agonist binding sites in the spontaneously hypertensive rat brain
D.R. Gehlert,James K. Wamsley +1 more
TL;DR: Results indicate that a selective loss of alpha 2 receptors in discrete brain cardiovascular control regions of the SHR may contribute to the elevated blood pressure seen in this strain.
References
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Journal ArticleDOI
Further evidence for a central hypotensive action of α-methyldopa in both the rat and cat
L. Finch,G. Haeusler +1 more
TL;DR: The results strongly suggest that the central actions of α‐methyldopa are important for its hypotensive effect, although a possible peripheral effect cannot be excluded.
Journal ArticleDOI
Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.
M. Henning,A. Rubenson +1 more
TL;DR: The formation ofα‐methylnoradrenaline from α‐MD was prevented after FLA‐63 but there was a significant increase in the amounts of α‐methyldopamine formed.
Journal ArticleDOI
Noradrenaline: central inhibitory control of blood pressure and heart rate.
TL;DR: The results suggest an inhibitory role of an α-adrenoceptor in the area of the nucleus tractus solitarii in the central control of blood pressure in anesthetized rats.
Journal ArticleDOI
α-sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
A. Heise,G. Kroneberg +1 more
TL;DR: It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.
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