α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Frans P. Nijkamp,Wybren de Jong +1 more
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Bilateral injections of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats.About:
This article is published in European Journal of Pharmacology.The article was published on 1975-06-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Baroreceptor & Angiotensin II.read more
Citations
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Book ChapterDOI
Catecholamines of the nucleus tractus solitarii and blood pressure regulation
TL;DR: Damage to the NTS in rats results in hypertension, which following an acute severe phase, may lead to chronic hypertension, and baroreceptor deafferentation appears to be an important factor for both these phases.
The Neurochemical and Stimulatory Effects of Putative Metabolites of 3,4-Methylenedioxyamphetamine and 3,4-Methylenedioxymethamphetamine
S. Y. Yeh,Fu-Lian HSUt,S. Army +2 more
TL;DR: In stimulatory studies, MDA and MDMA, but not their metabolites except alpha-methylepinephrine, which increased activity at 15 and 30 min, increased locomotor activity from 15 to 180 min following the drug administration, and decreased the concentration of serotonin in the frontal cortexes.
Book ChapterDOI
Application of Chemical Ionization MS to the Study of Regional Brain Catecholamine Metabolism in (S)-α-Methyldopa Treated Rats
TL;DR: The currently most widely accepted hypothesis, the central false neurotransmitter theory, proposes that (S)-α-MD is transported into the brain where it undergoes enzymatic decarboxylation to α-methyldopamine (α-MDA) which is oxidized toα-methylnorepinephrine ( α-MNE), and act as “central false neurotransmitters”.
References
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Journal ArticleDOI
Further evidence for a central hypotensive action of α-methyldopa in both the rat and cat
L. Finch,G. Haeusler +1 more
TL;DR: The results strongly suggest that the central actions of α‐methyldopa are important for its hypotensive effect, although a possible peripheral effect cannot be excluded.
Journal ArticleDOI
Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.
M. Henning,A. Rubenson +1 more
TL;DR: The formation ofα‐methylnoradrenaline from α‐MD was prevented after FLA‐63 but there was a significant increase in the amounts of α‐methyldopamine formed.
Journal ArticleDOI
Noradrenaline: central inhibitory control of blood pressure and heart rate.
TL;DR: The results suggest an inhibitory role of an α-adrenoceptor in the area of the nucleus tractus solitarii in the central control of blood pressure in anesthetized rats.
Journal ArticleDOI
α-sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
A. Heise,G. Kroneberg +1 more
TL;DR: It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.
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