A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
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9,355 citations
3,913 citations
Cites methods from "A Multigene Assay to Predict Recurr..."
...Thus the ROR predictor based on subtypes provides similar information as the OncotypeDx Recurrence Score for patients with ER-positive, node-negative disease.(4,5) Furthermore, the PAM50 assay provides a ROR score for all patients, including those with ER-negative disease, and is highly predictive of neoadjuvant response when considering all patients....
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...For example, the 21-gene OncotypeDx assay (Genome Health Inc, Redwood City, CA) can be used to risk stratify earlystage estrogen receptor (ER) –positive breast cancer.(4,5) Another strong predictor of outcome in ER-positive disease is proliferation or genomic grade....
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3,902 citations
Cites background from "A Multigene Assay to Predict Recurr..."
...For example, the 21-gene recurrence score (RS) assay includes ER and PgR as one of the genes in the signature.(11) However, comparison between measures of ER/PgR protein by local IHC and of mRNA by central reverse transcription polymerase chain reaction showed a discordance rate of 9% and 12%, respectively,(12) and there are no published correlations of the individual measures of ER and PgR mRNA from the 21-gene signature with clinical outcome....
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3,310 citations
Cites background from "A Multigene Assay to Predict Recurr..."
...Numerous transcriptome studies have defined general prostate cancer signatures, but, unlike breast cancer (Paik et al., 2004; van de Vijver et al., 2002), these analyses have not identified robust subtypes of prostate cancer with different prognoses (Febbo and Sellers, 2003; Lapointe et al....
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...Whereas transcriptome analysis defines breast cancer subgroups with distinct prognoses and treatment outcomes that have changed clinical practice (Paik et al., 2004; van de Vijver et al., 2002), similar studies in prostate cancer have been less clinically useful (Mucci et al....
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