A nano-Ni based ultrasensitive nonenzymatic electrochemical sensor for glucose: enhancing sensitivity through a nanowire array strategy.
TL;DR: A NiNWAs based electrode shows very high electrochemical activity for electrocatalytic oxidation of glucose in alkaline medium, which has been utilized as the basis of the fabrication of a nonenzymatic biosensor for electrochemical detection of glucose.
About: This article is published in Biosensors and Bioelectronics.The article was published on 2009-09-15. It has received 358 citations till now. The article focuses on the topics: Biosensor & Electrochemical gas sensor.
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TL;DR: This article concentrates mainly on the development of different nanostructured metal-oxide based glucose biosensors with high sensitivity, fast response times, and stability for the determination of glucose by electrochemical oxidation.
Abstract: Nanotechnology has opened new and exhilarating opportunities for exploring glucose biosensing applications of the newly prepared nanostructured materials. Nanostructured metal-oxides have been extensively explored to develop biosensors with high sensitivity, fast response times, and stability for the determination of glucose by electrochemical oxidation. This article concentrates mainly on the development of different nanostructured metal-oxide [such as ZnO, Cu(I)/(II) oxides, MnO2, TiO2, CeO2, SiO2, ZrO2, and other metal-oxides] based glucose biosensors. Additionally, we devote our attention to the operating principles (i.e., potentiometric, amperometric, impedimetric and conductometric) of these nanostructured metal-oxide based glucose sensors. Finally, this review concludes with a personal prospective and some challenges of these nanoscaled sensors.
649 citations
Cites methods from "A nano-Ni based ultrasensitive none..."
...This can be done by using: (1) inert metals such as Pt [25-27], Au [28-30] and Ni [31,32]; (2) metal alloys containing Pt, Au, Pb,...
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TL;DR: Co3O4 nanofibers have great potential applications in the development of sensors for enzyme-free detection of glucose and are demonstrated to have good reproducibility and selectivity in alkaline solution.
623 citations
TL;DR: The CuO/MWCNTs electrode exhibits an enhanced electrocatalytic property, low working potential, high sensitivity, excellent selectivity, good stability, and fast amperometric sensing towards oxidation of glucose, thus is promising for the future development of nonenzymatic glucose sensors.
592 citations
TL;DR: It is demonstrated that such novel Au NPs-N-GQDs nanocomposite is promising for fabrication of nonenzymatic H2O2 biosensors and has shown great potential applications for detection of H 2O2 levels in human serum samples and that released from human cervical cancer cells with satisfactory results.
Abstract: In this work, we report a green and simple strategy for the in situ growth of surfactant-free Au nanoparticles (Au NPs) on nitrogen-doped graphene quantum dots (Au NPs–N-GQDs). The formation of hybrid was achieved by just mixing the N-GQDs and HAuCl4·4H2O without addition of any other reductant and surfactant. High-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) characterizations clearly showed the formation of Au nanoparticles with predominantly exposed (111) facets which can provide more adsorption sites. Such nonsurfactant-capped Au NPs can provide naked catalytic surface with highly electrocatalytic activity. The Au NPs–N-GQDs exhibit high sensitivity and selectivity for electrochemical detection of hydrogen peroxide (H2O2) with a low detection limit of 0.12 μM and sensitivity of 186.22 μA/mM cm2. Importantly, the Au NPs–N-GQDs-based electrochemical biosensor has shown great potential applications for detection of H2O2 levels in ...
498 citations
TL;DR: This review outlines the current status and future direction for carbon nanomaterials to be used in the sensing area and discusses synthesis methods, up-to-date sensing approaches and nonenzymatic hybrid sensors.
Abstract: There has been an explosion of research into the physical and chemical properties of carbon-based nanomaterials, since the discovery of carbon nanotubes (CNTs) by Iijima in 1991. Carbon nanomaterials offer unique advantages in several areas, like high surface-volume ratio, high electrical conductivity, chemical stability and strong mechanical strength, and are thus frequently being incorporated into sensing elements. Carbon nanomaterial-based sensors generally have higher sensitivities and a lower detection limit than conventional ones. In this review, a brief history of glucose biosensors is firstly presented. The carbon nanotube and grapheme-based biosensors, are introduced in Sections 3 and 4, respectively, which cover synthesis methods, up-to-date sensing approaches and nonenzymatic hybrid sensors. Finally, we briefly outline the current status and future direction for carbon nanomaterials to be used in the sensing area.
440 citations
Cites methods from "A nano-Ni based ultrasensitive none..."
...Metal/metal oxide based catalysts, like Cu [73], CuO [74], MnO2 [75] and Ni [76] were applied to modify the electrodes for non-enzymatic determination of glucose....
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References
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TL;DR: The properties of glucose oxidase (GOD) are described in relation to the widespread use of this enzyme in biosensors, and the shortcomings of other enzymes that oxidize glucose are indicated.
1,189 citations
"A nano-Ni based ultrasensitive none..." refers background in this paper
...However, the activty of GOx can be easily affected by temperature, pH, humidity, nd toxic chemicals (Wilson and Turner, 1992)....
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TL;DR: In this article, a glucose biosensors based on carbon nanotube (CNT) nanoelectrode ensembles (NEEs) was developed for the selective detection of glucose.
Abstract: This paper describes the development of glucose biosensors based on carbon nanotube (CNT) nanoelectrode ensembles (NEEs) for the selective detection of glucose. Glucose oxidase was covalently immobilized on CNT NEEs via carbodiimide chemistry by forming amide linkages between their amine residues and carboxylic acid groups on the CNT tips. The catalytic reduction of hydrogen peroxide liberated from the enzymatic reaction of glucose oxidase upon the glucose and oxygen on CNT NEEs leads to the selective detection of glucose. The biosensor effectively performs a selective electrochemical analysis of glucose in the presence of common interferents (e.g., acetaminophen, uric and ascorbic acids), avoiding the generation of an overlapping signal from such interferers. Such an operation eliminates the need for permselective membrane barriers or artificial electron mediators, thus greatly simplifying the sensor design and fabrication.
857 citations
"A nano-Ni based ultrasensitive none..." refers background in this paper
...It can also be seen from the image that for most of the nanowires the spacing between two nanowires is larger than the diameter of the nanowire, making each nanowire work as an individual nanoelectrode (Lin et al., 2004)....
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TL;DR: An overview of the investigations carried out into nanoparticle formation, characterisation and employment for the detection of many electroactive species using gold, silver and platinum metals is given.
Abstract: Nanoparticles can display four unique advantages over macroelectrodes when used for electroanalysis: enhancement of mass transport, catalysis, high effective surface area and control over electrode microenvironment. Therefore, much work has been carried out into their formation, characterisation and employment for the detection of many electroactive species. This paper aims to give an overview of the investigations carried out in this field. Particular attention is paid to examples of the advantages and disadvantages nanoparticles show when compared to macroelectrodes and the advantages of one nanoparticle modification over another. Most work has been carried out using gold, silver and platinum metals. However, iron, nickel and copper are also reviewed with some examples of other metals such as iridium, ruthenium, cobalt, chromium and palladium. Some bimetallic nanoparticle modifications are also mentioned because they can cause unique catalysis through the mixing of the properties of both metals.
663 citations
"A nano-Ni based ultrasensitive none..." refers background in this paper
...…as such materials showed some unique features such as high surface areato-volume ratios, rapid mass transport, improved electrocatalytic activity as well as biocompatibility with comparison to bulk electrode metallic materials (Lin et al., 2005; Mena et al., 2005; Welch and Compton, 2006)....
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TL;DR: The preliminary study shows that the nonenzymatic sensor has synergistic electrocatalytic activity to the oxidation of glucose in alkaline media and has good reproducibility and long-term stability and is interference free.
531 citations
"A nano-Ni based ultrasensitive none..." refers background in this paper
...The ormal physiological level of glucose is about 3–8 mM, which is uch higher than the concentrations of interfering species like UA 0.1 mM) and AA (0.1 mM) (Kang et al., 2007; Safavi et al., 2009)....
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TL;DR: The GOx/CH-Fe(3)O(4)/ITO nanocomposite bioelectrode has response time of 5s, linearity as 10-400 mgdL(-1) of glucose, sensitivity as 9.3 microA/(mgdLcm(2)) and shelf life of about 8 weeks under refrigerated conditions.
423 citations