Journal ArticleDOI
A neurochemical theory of autism
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Panksepp et al. as discussed by the authors put forward the idea that autism is an emotional disturbance arising from an upset in the opiate systems in the brain, and hence proposed, as a possibility, opiate antagonist therapy for the autistic syndrome.About:
This article is published in Trends in Neurosciences.The article was published on 1979-01-01. It has received 303 citations till now. The article focuses on the topics: Autism.read more
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Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TL;DR: In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.
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Autism: Towards an Integration of Clinical, Genetic, Neuropsychological, and Neurobiological Perspectives
TL;DR: A partial integration of the causal processes leading to autism requires an integration across different levels of enquiry, and provides a useful strategy for identifying key research questions, the limitations of existing hypotheses, and future research directions that are likely to prove fruitful.
Journal ArticleDOI
Discriminative and Affective Touch: Sensing and Feeling
TL;DR: It is proposed that a class of low-threshold mechanosensitive C fibers that innervate the hairy skin represent the neurobiological substrate for the affective and rewarding properties of touch.
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Brain substrates of infant–mother attachment: Contributions of opioids, oxytocin, and norepinephrine.
Eric E. Nelson,Jaak Panksepp +1 more
TL;DR: It is proposed that these same neurochemical and neuroanatomical patterns will emerge as key substrates in the neurobiology of infant attachments to their caregivers.
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Annotation: Repetitive behaviour in autism: a review of psychological research.
TL;DR: The aim of this Annotation is to provide a review of what is known about repetitive behaviour in autism, its specificity to the syndrome, and the functions or mechanisms that might underlie this behaviour at the psychological level.
References
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The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system.
TL;DR: With the indirect immunofluorescence technique the distribution of methionine-enkephalin-immunoreactive cell bodies was studied in the central nervous system of rats pretreated with colchicine.
Journal Article
The biology of social attachments: opiates alleviate separation distress.
TL;DR: The possibility is entertained that brain opiates may function to control the intensity of emotions arising from social separation and parallels between the biological nature of narcotic addiction and the formation of social bonds are discussed.
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Morphine and enkephalin: analgesic and epileptic properties.
TL;DR: Findings support the view that the periaqueductal gray matter is actively involved in endogenous mechanisms of analgesia and suggest that endogenous enkephalin may play some role in epileptogenesis.
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Effects of morphine and naloxone on separation distress and approach attachment: evidence for opiate mediation of social affect.
Barbara H. Herman,Jaak Panksepp +1 more
TL;DR: The hypothesis that an endorphin-based addiction-like process may underlie the maintenance of social attachments, and that separation distress may reflect a state of endogenous "endorphin withdrawal", is supported.
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Endorphins: naloxone fails to alter experimental pain or mood in humans
TL;DR: In a double-blind procedure, intravenous doses of up to 10 milligrams of naloxone hydrochloride in saline were indistinguishable from similarly administered saline alone, and did not activate any functionally significant pain-attenuating or mood-altering effect of endorphins.