A new antibiotic, negamycin.
25 Mar 1970-The Journal of Antibiotics (JAPAN ANTIBIOTICS RESEARCH ASSOCIATION)-Vol. 23, Iss: 3, pp 170-171
About: This article is published in The Journal of Antibiotics.The article was published on 1970-03-25 and is currently open access. It has received 92 citations till now.
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TL;DR: As of early 2013, over 200 natural products are known to contain a nitrogen-nitrogen (N-N) bond and this report describes their isolation and biological activity.
Abstract: As of early 2013, over 200 natural products are known to contain a nitrogen-nitrogen (N-N) bond. This report categorizes these compounds by structural class and details their isolation and biological activity.
258 citations
TL;DR: This work reviews recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone through structural features, utility and preparative methods.
Abstract: Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure–activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.
206 citations
TL;DR: The molecular basis for PTC readthrough in eukaryotes is reviewed and currently available compounds with significant therapeutic potential for treating genetic disorders and cancer are described.
165 citations
TL;DR: Lavendomycin, a new basic peptide antibiotic containing novel amino acids, has been isolated from the culture broth of a streptomyces designated as StrePTomyces lavendulae subsp.
Abstract: Lavendomycin, a new basic peptide antibiotic containing novel amino acids, has been isolated from the culture broth of a streptomyces designated as Streptomyces lavendulae subsp. brasilicus. The antibiotic obtained as colorless crystals (C29H50N10O8, MW 666) is active against Gram-positive bacteria in vitro and in vivo, however, inactive against Gram-negative bacteria and fungi. An acute toxicity of the antibiotic in mice was LD50 greater than 2 g/kg by subcutaneous injection.
125 citations
TL;DR: The mechanisms that are involved in discriminating normal versus premature termination codons, the factors involved in readthrough efficiency, the epidemiology of several well-known nonsense-mediated diseases, and the various pharmacological agents that are currently being employed in nonsense suppression therapy studies are reviewed.
124 citations