A New Photochemical Reaction1
01 May 1960-Journal of the American Chemical Society (American Chemical Society)-Vol. 82, Iss: 10, pp 2640-2641
TL;DR: The photolysis of suitably constituted organic nitrites provokes an intramolecular exchange of the NO of the nitrite residue with a hydrogen atom attached to a carbon atom in the y-position.
Abstract: The photolysis of suitably constituted organic nitrites provokes an intramolecular exchange of the NO of the nitrite residue with a hydrogen atom attached to a carbon atom in the y-position. The C-nitroso compounds thus formed can be isolated as the corresponding nitrosodimers or, after isomerization , as the oximes. Adequate structural proof has been provided for several examples of the reaction. The mechanism of the process has been discussed and an interpretation of all the relevant facts presented.
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TL;DR: This tutorial review describes selected recent examples of how the metal-catalysed C-H bond functionalisation has been able to positively affect the synthesis of natural products.
Abstract: Metal-catalysed C–H bond functionalisation has had a significant impact on how chemists make molecules. Translating the methodological developments to their use in the assembly of complex natural products is an important challenge for the continued advancement of chemical synthesis. In this tutorial review, we describe selected recent examples of how the metal-catalysed C–H bond functionalisation has been able to positively affect the synthesis of natural products.
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TL;DR: This critical review of C-H functionalization logic will be analyzed through the critical lens of total synthesis, and takes the reader through a series of case studies in which it has already been successfully applied.
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