Journal ArticleDOI
A New Technique to Efficiently Entrap Leuprolide Acetate into Microcapsules of Polylactic Acid or Copoly(Lactic/Glycolic) Acid
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The aim of this work was to develop injectable microcapsules containing leuprolide acetate that would deliver that drug at a zero-order rate over a period of about one month, but the release profiles of the drug in vitro were inadequate for controlled release for one month.Abstract:
The aim of this work was to develop injectable microcapsules containing leuprolide acetate, that would deliver that drug at a zero-order rate over a period of about one month. A large amount of leuprolide acetate, a hydrophilic drug, was entrapped into polylactic aicd (PLA) and copoly-(lactic/glycolic) acid (PLGA) microcapsules prepared by an in-water dring method using a (w/o)/w emulsion. The basic techniques were designed to increase the viwcosities of the inner water phase and w/o emulsion. Under the conditions used, it was possible for the drug to be completely entrapped by the microcapsules in the range of 10 to 20% on the basis of the polymer. However, the release profiles of the drug in vitro were inadequate for controlled release for one month.read more
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The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.
TL;DR: This review discusses the various traditional and novel techniques (such as in situ microencapsulation) of preparing various drug loaded PLGA devices, with emphasis on preparing microparticles.
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Medical devices and applications of polyhydroxyalkanoate polymers
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Journal ArticleDOI
Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.
Raghavendra C. Mundargi,V. Ramesh Babu,Vidhya Rangaswamy,Pradip Shantibhai Patel,Tejraj M. Aminabhavi +4 more
TL;DR: Important findings of the past decade on the encapsulation and release profiles of macromolecular therapeutics from PLGA and PLGA-based nano/microparticles are discussed critically in relation to nature and type of bioactive molecule, carrier polymer and experimental variables that influence the delivery of macrochemical therapeutics.
Journal ArticleDOI
Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres
TL;DR: Stability studies showed that the encapsulation of an enzyme inside PLGA microspheres can protect them from activity loss, and in vitro release studies revealed that different release profiles and release rates can be achieved by simply modifying factors in the preparation procedure.
Journal ArticleDOI
Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology.
TL;DR: The findings will be outlined according to the four major substeps of microsphere preparation by solvent extraction/evaporation, namely, incorporation of the bioactive compound, formation of the microdroplets, solvent removal and harvesting and drying the particles.