A newly defined risk signature, consisting of three m 6 A RNA methylation regulators, predicts the prognosis of ovarian cancer
Lili Fan,Ying Lin,Han Lei,Guang Shu,Liuer He,Zhipeng Yan,Hai Rihan,Gang Yin +7 more
- Vol. 12, Iss: 18, pp 18453-18475
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TLDR
Wang et al. as mentioned in this paper analyzed the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive, and they demonstrated that the 18 central m6a RNA methylization regulators were expressed differently between ovarian cancer (OC) and normal tissues.Abstract:
N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 central m6A RNA methylation regulators were expressed differently between ovarian cancer (OC) and normal tissues. By applying consensus clustering, all ovarian cancer patient cases can be divided into three subgroups (cluster1/2/3) based on overall expression levels of all 18 m6A RNA methylation regulators. We systematically analyzed the prognostic value of transcription levels of 18 m6A RNA methylation regulators in ovarian cancer and found that insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1), vir like m6A methyltransferase associated (VIRMA), and zinc finger CCCH-type containing 13 (ZC3H13) yield the highest scores for predicting the prognosis of ovarian cancer. Accordingly, we derived a risk signature consisting of transcription levels of these three selected m6A RNA methylation regulators as an independent prognostic marker for OC and validated our findings with data derived from a different ovarian cancer cohort. Moreover, by the Gene Set Enrichment Analysis (GSEA), we demonstrated that the three selected regulators were all correlated with pathways in cancer and WNT signaling pathways. In conclusion, m6A RNA methylation regulators are vital participants in ovarian cancer pathology; and IGF2BP1, VIRMA, and ZC3H13 mRNA levels are valuable factors for prognosis prediction and treatment strategy development.read more
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Journal ArticleDOI
Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer.
TL;DR: Wang et al. as discussed by the authors comprehensively assessed m1A modification patterns in 474 ovarian cancer patients and linked them to TME immune infiltration characteristics, showing that individual tumor m1a modification patterns can predict patient survival, stage and grade.
Journal ArticleDOI
Expression and molecular profiles of the AlkB family in ovarian serous carcinoma
TL;DR: In this paper, the molecular profiles of AlkB family in OV have not been clarified, and the results indicated that the expression of ALKBH1/3/5/8 and FTO was lower in ovarian serous carcinoma (OV) patients while AlKBH2/4/6/7 expression was higher.
Journal ArticleDOI
Role of m6A methyltransferase component VIRMA in multiple human cancers (Review)
TL;DR: In this article, the role of vir-like m6A methyltransferase associated (VIRMA) is investigated in various types of cancer and the mechanisms of VIRMA promoting cancers provided the basis for potential therapeutic targeting for cancer treatments.
Journal ArticleDOI
RNA m6A methylation regulators in ovarian cancer.
TL;DR: A review of the latest studies on m6A and its regulators in ovarian cancer has been summarized in this article, focusing on the key role of m6a modification in the development and progression of OC.
Journal ArticleDOI
Emerging Roles of m6A RNA Methylation Regulators in Gynecological Cancer
TL;DR: The regulatory mechanism, biological functions, and therapeutic prospects of m6A RNA methylation regulators in gynecological cancers are reviewed.
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