A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Citations
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Cites background or methods from "A Next Generation Connectivity Map:..."
...We also queried the TCM gene expression signatures to the latest version of Connectivity Map for potential mechanism of action (MoA) evidence of the TCM against GWAS diseases....
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...We utilized the latest Connectivity Map (CMap) CLUE web application (https://clue.io) resource for identifying MoA for these TCM components [8, 9]....
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...Furthermore, the MoA of these TCM against the GWAS disease could be supported by Connectivity Map analysis....
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...We performed a permutation based testing as below to obtain the nominal p value (P) similar to the approach of Connectivity Map [8, 9]:...
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...We performed literature and molecular mechanisms evidence by querying PubMed and the Connectivity Map to support the GWAS disease-TCM gene pairs....
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6 citations
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References
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