A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
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Cites background or methods from "A Next Generation Connectivity Map:..."
...Analysis of the association between HDAC inhibitors and expression of HIF-1α In the present study we analyzed the L1000 gene expression dataset in the Connectivity Map [18] which was obtained from the Broad Institute (https://clue.io/data/GCTX#GCTxDatasets)....
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...The analysis of dataset generated by treating diverse cell types with pharmacological and genetic perturbagens has been proposed to discover the functional connections between genes, drugs, and diseases [18, 19]....
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...In short, the L1000 is a highthroughput gene expression assay that measures the expression of 978 “landmark” genes from human cells [18] which can be used to computationally infer the expression of 11,350 genes....
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...To address this knowledge gap, in this present study we conducted a computational analysis of high-throughput expression profiling dataset [18] to evaluate the association between HDAC6 inhibitors and gene expression of HIF-1α....
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...expression of HIF-1α In the present study we analyzed the L1000 gene expression dataset in the Connectivity Map [18] which was obtained from the Broad Institute (https://clue....
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References
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