A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Citations
3 citations
Cites background from "A Next Generation Connectivity Map:..."
...The expression values of landmark genes are measured directly from the L1000 platform, which can represent approximately 82% information [63]....
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...Library of Integrated Network-Based Cellular Signatures (LINCS) program was proposed to create a network-based understanding of biology [63]....
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3 citations
Cites background or methods from "A Next Generation Connectivity Map:..."
...There are currently 1.3 million microarray samples in the LINCS data repository capturing the effect of numerous chemical and genetic perturbations on gene expression (Subramanian et al., 2017)....
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...For this scenario we used 964 “landmark” genes from LINCS as the measured genes to impute the expression of all the other genes in the genome-scale Affymetrix Human Genome U133 Plus 2.0 Array (15,991 unmeasured genes) (Subramanian et al., 2017; Chen et al., 2016)....
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...The most prominent example of this effort is the Library of Integrated Network-Based Cellular Signatures (LINCS) microarray program (Subramanian et al., 2017), which has shown that measuring 978 “landmark” genes, costing only $5 per sample (Peck et al., 2006), is sufficient to then use to impute…...
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References
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