A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
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Cites background or methods from "A Next Generation Connectivity Map:..."
...To validate drug diffusion 671 profiles, we compare drug diffusion profiles to the drug gene expression signatures present in the 672 Broad Connectivity Map [48, 49] (Figure 2f)....
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...8 × 10-7, n = 152) [48, 49], indicating that diffusion 168 profiles reflect the effects of drugs on proteins and biological functions....
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...To accomplish this, we follow Broad 679 Connectivity Map guidelines [48, 49] as described next....
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Cites background from "A Next Generation Connectivity Map:..."
...While it may be feasible to use external datasets, such as the LINCS small molecule L1000 transcriptional signatures [18,44], additional target-based screening datasets in PubChem, or molecule activity data in ChEMBL, these external datasets do not include all Tox21 compounds, and they may not be a generally accepted reference gold standard....
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