A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Citations
30 citations
Cites methods from "A Next Generation Connectivity Map:..."
...Five different variants of each cell type were created by introducing different pairs of green and red markers: (1) GFP-ACTB (actin cytoskeleton) and RFP-RAB5A (early endosome), (2) CANX-GFP (endoplasmic reticulum) and COX4I1-RFP (mitochondria), (3) GFP-GM130 (Golgi) and FusionRed-SQSTM1 (autophagosome), (4) GFP-TUBA1B (microtubules) and FusionRed-RELA (NF-κB signalling), and (5) GFP-TP53BP1 (non-homologous end joining-mediated repair of DNA double strand breaks) and CLTA-FusionRed (clathrin-mediated endocytosis)....
[...]
30 citations
30 citations
Cites background from "A Next Generation Connectivity Map:..."
...Themain power of genome-wide transcript modeling is that the signatures generated can be used as powerful tools to investigate chronic disease and identify potential treatments (Chang et al., 2015b; Subramanian et al., 2017; Timmons et al., 2005)....
[...]
30 citations
30 citations
References
34,830 citations
30,124 citations
10,968 citations
8,326 citations
6,319 citations