A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Citations
1,099 citations
Cites methods from "A Next Generation Connectivity Map:..."
...To further investigate about mechanism of actions (MoA) and drug-target we performed specific analysis within Connectivity Map tools (https://clue.io/) (Subramanian et al., 2017)....
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...Connectivity Map (CMap) was recently updated (September 2017) (Subramanian et al., 2017), providing the end-users new functionalities and new graphical interface as web-server, previous registration (https://clue.io/) allowing easily the extraction of druginteraction knowledge using as input a…...
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794 citations
Cites background or methods from "A Next Generation Connectivity Map:..."
...Moreover, there is a significant overlap between the perturbations that reverse the expression of the program’s repressed and induced components (p = 4.353 10 6, hypergeometric test), including the overexpression of IFN-g and IFN-b and the knockdown of MYC and CDK7 (Subramanian et al., 2017)....
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...Three genes (CDKN2C/ p18, CDKN1B/p27, andCDKN1A/p21) that inhibit CDK4 repress the program when overexpressed (Subramanian et al., 2017) (STARMethods), and the program ismore pronounced in cycling cells (Figures 1E, 2C, and S2E), where CDK4/6 are active....
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...The latter mirrors the significantly large number of Myc and CDK7 (direct) targets (Oki et al., 2018; Subramanian et al., 2005) in the program (p < 1 3 10 17, hypergeometric test)....
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...Indeed, the programs are enriched for Myc targets, even after removing RP genes (p 7.18 3 10 10) and are predicted to be repressed byMYC knockdown according to the Connectivity Map (Subramanian et al., 2017)....
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...353 10 (6), hypergeometric test), including the overexpression of IFN-g and IFN-b and the knockdown of MYC and CDK7 (Subramanian et al., 2017)....
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References
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"A Next Generation Connectivity Map:..." refers background in this paper
...Alternative probe-selection methods, however, have been proposed (Donner et al., 2012)....
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19 citations
"A Next Generation Connectivity Map:..." refers background in this paper
...1444 Cell 171, 1437–1452, November 30, 2017 ported (Rovedo et al., 2011), and the biochemical profiling confirms that enzastaurin is indeed also a potent GSK3 inhibitor with a KD of 8 nM (Davis et al....
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