A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
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...Furthermore, a recent study showed that CoA biosynthesis can be targeted by a chemically diverse set of inhibitors that do not resemble pantothenate, the most potent of which had a 50% inhibitory concentration (IC50; the concentration that inhibits parasite proliferation by 50%) of 120 nM against blood-stage parasites (12)....
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"A novel approach for the discovery ..." refers background in this paper
...This clearly demonstrates the need for anti-malarial drugs with novel mechanisms of action and/or of different chemical origin to effectively counteract the development of resistance, thus reinforcing the current defense against malaria [3,4]....
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"A novel approach for the discovery ..." refers methods in this paper
...falciparum strain 3D7 was independently assessed using an established imagebased growth inhibition assay [14,15]....
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"A novel approach for the discovery ..." refers background in this paper
...For pantothenate kinase, the enzyme catalysing the first and rate-limiting step of CoA synthesis [11], the maximal amino acid sequence homology between the known human isotypes and the two putative P....
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...Despite the conservation of the five enzymatic steps involved in CoA synthesis in eukaryotes [11], the amino acid sequence of the enzymes involved are not highly conserved between species [7]....
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