A Novel Double Fault Diagnosis and Detection Technique in Digital Microfluidic Biochips
24 Sep 2015-Vol. 9339, pp 181-192
TL;DR: The proposed algorithm detects double faults anywhere in the chip satisfying the dynamic fluidic constraints and improves the fault diagnosis time to an extent.
Abstract: This paper presents a rigorous offline double fault diagnosis as well as a detection technique for Digital Microfluidic Biochips (DMFBs). Due to the underlying mixed technology biochips exhibit unique failure mechanisms and defects. Thus, offline and online test mechanisms are required to certify the dependability of the system. In this paper, the proposed algorithm detects double faults anywhere in the chip satisfying the dynamic fluidic constraints and improves the fault diagnosis time to an extent.
Citations
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TL;DR: An efficient fault detection mechanism is formulated to identify multiple numbers of defective/faulty electrodes on an m × n biochip array, where m and n can be of any positive number.
Abstract: The involvement of Digital Microfluidic Biochips (DMFBs) in the field of disease detection, automated drug discovery, on-chip DNA (Deoxyribonucleic acid) analysis has become well-accepted d...
3 citations
Cites background or methods from "A Novel Double Fault Diagnosis and ..."
...Three major components in a biochip are 2Dmicrofluidic array, dispensing ports/reservoirs, and optical detectors [12] (see Figure 1)....
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...Multiple and double fault detection techniques have been proposed in [11] and [12], respectively, by Chowdhury et al....
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TL;DR: An aspect of fast fault diagnosis appliance for perceiving double faults and recognizing the fault locations within the biochip is introduced and the suggested result outpoured that the propound technique is competent, efficacious as well as delineate signifying improvement over the surviving method.
Abstract: Progress of digital microfluidic biochip (DMFB) confronts for the defective and specious electrodes. Not only these hinder the routing of droplets but also the completion time of assay is influenced by those defective electrodes. As Microfluidic-based biochips are broadly used in the revolution of medical diagnosis, gigantic parallel DNA analysis, automatic drug discovery and real-time biomolecular recognition including numerous safety-critical applications, this biochip definitely responsible for appropriate and accurate result. Prior accepting it for perceptive purposes the microfluidic biochip must confirm its precision and robustness. In this article, an aspect of fast fault diagnosis appliance for perceiving double faults and recognizing the fault locations within the biochip is introduced. If the biochip is defect free then the proposed approach computes the traversal time as well. The suggested result outpoured that the propound technique is competent, efficacious as well as delineate signifying improvement over the surviving method. Furthermore this paper added expedient reconfiguration contrivance.
2 citations
Cites background or methods from "A Novel Double Fault Diagnosis and ..."
...Comparison of proposed technique with existing technique [23, 39]...
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...diagnosis technique could be comprehended from [23]....
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...Matrix Size Proposed Existing [23, 39] Improvement (%) 4×4 17 24 29....
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...Next we have presented the comparative studies of the proposed technique with [23, 39], [22, 33] and [43] in Table 4, 5 and 6 respectively....
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...On the other hand, multiple fault detection is not an indicative of intelligence; as detection of multiple faults is very intricate grind [23]....
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References
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18 Jun 2008
TL;DR: This paper describes a droplet routing technique for a fault-tolerant digital microfluidic platform that features handling of many microfluidity operations simultaneously and uses on-chip sensors for diagnosis at run-time.
Abstract: Efficient droplet routing is one of the key approaches for realizing fault-tolerant microfluidic biochips. It requires that run-time diagnosis and fault recovery can be made possible in such systems. This paper describes a droplet routing technique for a fault-tolerant digital microfluidic platform. This technique features handling of many microfluidic operations simultaneously and uses on-chip sensors for diagnosis at run-time. Once a fault is detected during the droplet routing, recovery procedures will be started-up immediately. Faulty units on the chip will be marked and isolated from the array so that the remaining droplets can still be routed along a fault-free path to their destinations. This method guarantees a non-stop fault-tolerant operation for very large microfluidic arrays.
12 citations
"A Novel Double Fault Diagnosis and ..." refers background in this paper
...Droplet routing on the surface of the microfluidic biochip has been attracting much attention in recent years as it is one of the key issues to make use of the digital microfluidic device efficiently [3]....
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18 May 2012
TL;DR: Specific types of faults that may occur in cross referencing biochips are identified and techniques for detection and location of such faults are developed with the objective of optimum resource utilization and minimum consumption of time.
Abstract: In recent time's digital microfluidics have gained much attention as an emerging technology that provides automation in fluid handling within a miniaturized substrate. Compared to traditional bench-top procedures, microfluidic biochips offer the advantages of low sample and reagent consumption, less likelihood of error due to minimal human intervention, high throughput, and high sensitivity. With the increase in number of bioassays for concurrent operation to be mapped in a single digital microfluidic platform needs for design automation as well as testing and fault diagnosis techniques become highly relevant for better accuracy in results and efficiency in operation. In spite of individual and independent control of electrodes -a new droplet manipulation method based on a “cross-referencing” mode that uses “row” and “columns” to access electrodes has recently come into use. The cross referencing technology largely scales down the control pin number on chip, which not only brings down manufacturing cost but also enables larger number of bioassay integration on a single biochip platform. However, the cross-referencing scheme due to severe electrode interference and other defects can result in faulty operations which in turn cause erroneous results or complete malfunction of the device. In this paper we tried to identify specific types of faults that may occur in cross referencing biochips and developed techniques for detection and location of such faults with the objective of (i) optimum resource utilization and (ii) minimum consumption of time. Testing simulation has been carried out with different size of 2D grids and with different number of test droplets and the corresponding results are found to be encouraging.
7 citations
"A Novel Double Fault Diagnosis and ..." refers background in this paper
...However, it should be taken care that each of the droplets is satisfying the observable fact of fluidic constraints described in [15]....
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...However, it is not supported by the concept of Fluidic constraints, which has been explained in [15]....
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01 Jan 2013
TL;DR: A new advance technique to traverse all the cells and cell boundary in much more less time compared to some previous technique to detect multiple faults for digital micro fluidic based biochips is presented.
Abstract: Faults in biochips degrades the performance of the biochips. This paper describes a new multiple fault detection technique for digital micro fluidic based biochips. The microfluidic based biochips are most important revolutionizing laboratory procedures use at a vast scale, e.g., bio sensing, clinical diagnostics etc. Due to mixed energy domains this micro fluidic based biochip exhibits unique failure mechanism and need to be error free to ensure system dependability. In this paper a new advance technique is presented to traverse all the cells and cell boundary in much more less time compared to some previous technique to detect multiple faults.
3 citations
"A Novel Double Fault Diagnosis and ..." refers methods in this paper
...A more advanced multiple fault detection technique has been proposed in [16] by Chowdhury et al....
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