A novel hemostat and antibacterial nanofibrous scaffold based on poly(vinyl alcohol)/poly(lactic acid):
28 Apr 2020-Journal of Bioactive and Compatible Polymers (SAGE PublicationsSage UK: London, England)-Vol. 35, Iss: 3, pp 189-202
TL;DR: This study aimed to present a novel scaffold with both abilities simultaneously - blood coagulation and bioavailability indexes and Morphological results showed that the hybrid nanofibers were form successfully.
Abstract: Today, an advanced wound dressing with the ability of blood clotting and antibacterial activity is the main subject of many studies to consider their necessity in modern society. In this study, it ...
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TL;DR: This paper aims to present the biomaterial dressings and scaffolds suitable for wound management application, reviewing the most recent studies in the field.
Abstract: Whether they are caused by trauma, illness, or surgery, wounds may occur throughout anyone’s life. Some injuries’ complexity and healing difficulty pose important challenges in the medical field, demanding novel approaches in wound management. A highly researched possibility is applying biomaterials in various forms, ranging from thin protective films, foams, and hydrogels to scaffolds and textiles enriched with drugs and nanoparticles. The synergy of biocompatibility and cell proliferative effects of these materials is reflected in a more rapid wound healing rate and improved structural and functional properties of the newly grown tissue. This paper aims to present the biomaterial dressings and scaffolds suitable for wound management application, reviewing the most recent studies in the field.
42 citations
01 Jul 2020
TL;DR: The main aim of this work was to fabricate the wound dressings using the electrospinning method blending Tranexamic acid with Polyvinyl alcohol to investigate the blood coagulation properties and the antibacterial properties.
Abstract: Health care professionals have always had problems treating and healing wounds Today, many of these problems have been resolved with the use of advanced wound dressings The main aim of this work was to fabricate the wound dressings using the electrospinning method blending Tranexamic acid (TXA) with Polyvinyl alcohol (PVA) to investigate the blood coagulation properties Also, the blending of Ceftriaxone (CTX) with Polyvinyl alcohol (PVA) was done to consider antibacterial properties The effects of drug concentration changes on these properties were also considered Morphological results demonstrated that nanofiber was produced uniformly and without beads SEM image indicated that the average diameter of the nanofiber of PVA with 10 and 20 mg/ml of TXA was 110, 124 nm, respectively and the average diameter of PVA nanofibers was with 01, 1, 8 µg/ml of CTX was 258, 273 and 379 nm, respectively The antibacterial properties of Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) were studied and the results demonstrated that the antibacterial properties increased with increasing MIC In PVA/CTX dressing with MIC: 8 μg/ml reached 100% Both PVA-TXA (10 mg/ml) and PVA-TXA (20 mg/ml) dressings demonstrated the acceptable ability of blood coagulation PVA-TXA (20 mg/ml) with an average absorption of 0031 had higher blood coagulation ability
21 citations
TL;DR: The top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days.
Abstract: Curcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers showed strong antibacterial activity against Staphylococcus aureus. Our results demonstrated the potential of bilayered nano/microfibrous membranes to be applied in the design of wound dressings containing active compounds susceptible to photodegradation.
16 citations
TL;DR: In this paper, a novel antimicrobial and hydrophilic nanofiber biomaterial was fabricated with a combination of surface modification and nanotechnology, in which poly(lactic acid) (PLA) bearing quaternary ammonium salt as an antimicrobial agent on its backbone was successfully fabricated by combining ring-opening copolymerization and copper(I)-catalysed azide-−alkyne cycloaddition click reaction in a two-step reaction procedure.
12 citations
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References
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TL;DR: In this article, a comprehensive review is presented on the researches and developments related to electrospun polymer nanofibers including processing, structure and property characterization, applications, and modeling and simulations.
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TL;DR: Improvements in early hemorrhage control and resuscitation and the prevention and aggressive treatment of coagulopathy appear to have the greatest potential to improve outcomes in severely injured trauma patients.
Abstract: The world-wide impact of traumatic injury and associated hemorrhage on human health and well-being cannot be overstated. Twelve percent of the global disease burden is the result of violence or accidental injury. Hemorrhage is responsible for 30 to 40% of trauma mortality, and of these deaths, 33 to 56% occur during the prehospital period. Among those who reach care, early mortality is caused by continued hemorrhage, coagulopathy, and incomplete resuscitation. The techniques of early care, including blood transfusion, may underlie late mortality and long-term morbidity. While the volume of blood lost cannot be measured, physiologic and chemical measures and the number of units of blood given are readily recorded and analyzed. Improvements in early hemorrhage control and resuscitation and the prevention and aggressive treatment of coagulopathy appear to have the greatest potential to improve outcomes in severely injured trauma patients.
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TL;DR: The materials, techniques and post modification methods to functionalize electrospun nanofibrous scaffolds suitable for biomedical applications are reviewed.
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TL;DR: Histological examination indicates that the rate of epithelialization is increased and the dermis becomes well organized if wounds are covered with electrospun nanofibrous membrane, which has potential applications for wound dressing based upon its unique properties.
Abstract: Produced via electrospinning, polyurethane membrane, which has a unique property, has been of interest in medical fields. Electrospinning is a process by which nanofibers can be produced by an electrostatically driven jet of polymer solution. Electrospun fibers are collected in the form of membranes. The porous structured electrospun membrane is particularly important for its favorable properties: it exudates fluid from the wound, does not build up under the covering, and does not cause wound desiccation. The electrospun nanofibrous membrane shows controlled evaporative water loss, excellent oxygen permeability, and promoted fluid drainage ability, but still it can inhibit exogenous microorganism invasion because its pores are ultra-fine. Histological examination indicates that the rate of epithelialization is increased and the dermis becomes well organized if wounds are covered with electrospun nanofibrous membrane. This electrospun membrane has potential applications for wound dressing based upon its unique properties.
797 citations
TL;DR: This study demonstrated for the first time, the application of polyphosphate as a hemostatic adjuvant, and developed a new chitosan-based composite with potent he mostatic and antimicrobial properties.
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