A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions
Citations
269 citations
Additional excerpts
...Establishment of a model of prostrate bone metastatic cancer [98]...
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Cites background from "A novel patient-derived intra-femor..."
...The most common site of metastasis for prostate cancer is bone, and frequently metastasis is symptomatic, with pain, debility, and functional impairment [2]....
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53 citations
References
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"A novel patient-derived intra-femor..." refers background in this paper
...Genome-wide expression and integrative genomic profiling have comprehensively shown that there are differences between cell lines in vitro compared with primary patient tumors [35-37]....
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...Next-generation genomic DNA sequencing and RNASeq profiling of expression and splice isoforms have revealed significant molecular diversity and complexity of prostate cancers [35-37]....
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2,825 citations
"A novel patient-derived intra-femor..." refers background or methods in this paper
...Tumor specimen was prepared aseptically in biohazard safety cabinet according to standard protocols with minor modifications [28,43-47]....
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...These biomarkers identified PCSD1 as an advanced luminal prostate cancer bone metastatic cancer [43-47,56,63,64]....
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...molecular analysis showed that PCSD1 is a luminal epithelial-type advanced prostate cancer [43-47]....
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2,320 citations
"A novel patient-derived intra-femor..." refers background in this paper
...It is essential, therefore, to develop new patient-derived, orthotopic bone metastasis prostate cancer xenograft models that are closer to patients’ original tumors especially for determining predictive therapy response profiles [39-42]....
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