A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure
Citations
172 citations
Cites background from "A Novel Porcine Circovirus Distantl..."
...PCV3 is associated with porcine dermatitis, nephropathy syndrome and reproductive failure (Palinski et al., 2016) and cardiac and multisystemic inflammation (Phan et al., 2016) ....
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...PCV3 has been identified as a pathogen agent associated with pig diseases (Palinski et al., 2016 ...
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...In 2016, a novel circovirus, called PCV type 3 (PCV3), was reported to exist in the USA (Palinski et al., 2016) ....
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150 citations
Cites background or methods from "A Novel Porcine Circovirus Distantl..."
...Moreover, PCV3 DNA was detected in heart lesions by in situ hybridization, and PCV3 antigen in skin, kidney, lung and lymph node samples from sows with PDNS lesions by immunohistochemistry (Palinski et al., 2017; Phan et al., 2016)....
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...The reports from USA and China described a frequent incidence of PCV3 in samples from pigs with different disease signs, free from other known pathogens (Phan et al., 2016; Palinski et al., 2017; Shen et al., 2017; Ku et al., 2017)....
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...Selected samples with the lowest Ct value were subjected to PCR targeting an ORF2 fragment and the amplicons were submitted for nucleotide sequencing (Palinski et al., 2017)....
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...More recently, Palinski et al. (2017) identified PCV3 in sows with skin lesions consistent with porcine dermatitis and nephropathy syndrome (PDNS), as well as in mummified foetuses aborted from such sows....
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...Additionally, PCV3 was detected in samples from 45 of 48 cases with lesions consistent with PDNS from 2010 to 2016, as well as in 34 of 271 lung, oral fluid or nasal swabs samples from respiratory disease cases (Palinski et al., 2017)....
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147 citations
132 citations
Cites background from "A Novel Porcine Circovirus Distantl..."
...All rights reserved circovirus 3 (PCV3), was originally identified by metagenomics in tissues of pigs suffering from PDNS, reproductive failure, myocarditis or multisystemic inflammation (Palinski et al., 2017; Phan et al., 2016)....
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...All rights reserved circovirus 3 (PCV3), was originally identified by metagenomics in tissues of pigs suffering from PDNS, reproductive failure, myocarditis or multisystemic inflammation (Palinski et al., 2017; Phan et al., 2016)....
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122 citations
References
1,492 citations
"A Novel Porcine Circovirus Distantl..." refers methods in this paper
...First-strand cDNA synthesis of viral DNA was performed with the Superscript III first-strand synthesis kit in accordance with the manufacturer’s instructions with previously published primers (77)....
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564 citations
"A Novel Porcine Circovirus Distantl..." refers background in this paper
...Further examination of the rep ORF protein sequence revealed conserved rolling-circle replication (RCR) motifs and a P-loop motif similar to those of goose circovirus (GoCV) and pigeon circovirus (PiCV) (30, 32)....
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536 citations
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450 citations
"A Novel Porcine Circovirus Distantl..." refers background in this paper
...Interestingly, CanineCV was identified in the liver of a dog displaying necrotizing vasculitis and granulomatous lymphadenitis, both of which were observed in PCV3-infected sows, as well as reported in PCV2 infections (22, 73, 74)....
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...By itself, PCV2 infection is typically subclinical (22)....
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